Research Priorities in Atrial Fibrillation Screening: A Report from a National Heart, Lung, and Blood Institute Virtual Workshop

Emelia J. Benjamin, Alan S. Go, Patrice Desvigne-Nickens, Christopher D. Anderson, Barbara Casadei, Lin Y. Chen, Harry J.G.M. Crijns, Ben Freedman, Mellanie True Hills, Jeff S. Healey, Hooman Kamel, Dong Yun Kim, Mark S. Link, Renato D. Lopes, Steven A. Lubitz, David D. McManus, Peter A. Noseworthy, Marco V. Perez, Jonathan P. Piccini, Renate B. SchnabelDaniel E. Singer, Robert G. Tieleman, Mintu P. Turakhia, Isabelle C. Van Gelder, Lawton S. Cooper, Sana M. Al-Khatib

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Clinically recognized atrial fibrillation (AF) is associated with higher risk of complications, including ischemic stroke, cognitive decline, heart failure, myocardial infarction, and death. It is increasingly recognized that AF frequently is undetected until complications such as stroke or heart failure occur. Hence, the public and clinicians have an intense interest in detecting AF earlier. However, the most appropriate strategies to detect undiagnosed AF (sometimes referred to as subclinical AF) and the prognostic and therapeutic implications of AF detected by screening are uncertain. Our report summarizes the National Heart, Lung, and Blood Institute's virtual workshop focused on identifying key research priorities related to AF screening. Global experts reviewed major knowledge gaps and identified critical research priorities in the following areas: (1) role of opportunistic screening; (2) AF as a risk factor, risk marker, or both; (3) relationship between AF burden detected with long-term monitoring and outcomes/treatments; (4) designs of potential randomized trials of systematic AF screening with clinically relevant outcomes; and (5) role of AF screening after ischemic stroke. Our report aims to inform and catalyze AF screening research that will advance innovative, resource-efficient, and clinically relevant studies in diverse populations to improve the diagnosis, management, and prognosis of patients with undiagnosed AF.

Original languageEnglish (US)
Pages (from-to)372-388
Number of pages17
Issue number4
StatePublished - Jan 26 2021

Bibliographical note

Publisher Copyright:
© 2021 Lippincott Williams and Wilkins. All rights reserved.


  • atrial fibrillation
  • diagnostic screening programs
  • prevention and control
  • research
  • stroke
  • User-Computer Interface
  • National Heart, Lung, and Blood Institute (U.S.)
  • United States
  • Humans
  • Treatment Outcome
  • Mass Screening
  • Education
  • Biomedical Research
  • Aged
  • Atrial Fibrillation/diagnosis

PubMed: MeSH publication types

  • Review
  • Research Support, Non-U.S. Gov't
  • Journal Article
  • Research Support, N.I.H., Extramural


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