Research gaps in primary pediatric hypertension

Perdita Taylor-Zapata, Carissa M. Baker-Smith, Gilbert Burckart, Stephen R. Daniels, Joseph T. Flynn, George Giacoia, Dionna Green, Aaron S. Kelly, Mona Khurana, Jennifer S. Li, Charlotte Pratt, Elaine M. Urbina, Anne Zajicek

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Hypertension affects .40% of the US population and is a major contributor to cardiovascular-related morbidity and mortality. Although less common among children and adolescents, hypertension affects 1% to 5% of all youth. The 2017 Clinical Practice Guideline for the Diagnosis and Management of High Blood Pressure in Children and Adolescents provided updates and strategies regarding the diagnosis and management of hypertension in youth. Despite this important information, many gaps in knowledge remain, such as the etiology, prevalence, and trends of hypertension; the utility and practicality of ambulatory blood pressure monitoring; practical goals for lifestyle modification that are generalizable; the long-term end-organ impacts of hypertension in youth; and the long-term safety and efficacy of antihypertensive therapy in youth. The Eunice Kennedy Shriver National Institute of Child Health and Human Development, in collaboration with the National Heart, Lung, and Blood Institute and the US Food and Drug Administration, sponsored a workshop of experts to discuss the current state of childhood primary hypertension. We highlight the results of that workshop and aim to (1) provide an overview of current practices related to the diagnosis, management, and treatment of primary pediatric hypertension; (2) identify related research gaps; and (3) propose ways to address existing research gaps.

Original languageEnglish (US)
Article numberY
Issue number5
StatePublished - May 2019

Bibliographical note

Funding Information:
The September 2017 Best Pharmaceuticals for Children Act Primary Pediatric Hypertension Workshop sponsored by the Eunice Kennedy Shriver National Institute of Child Health and Human Development; the National Heart, Lung, and Blood Institute; and the US Food and Drug Administration culminated in the creation of this article. Funded by the National Institutes of Health (NIH).

Publisher Copyright:
Copyright © 2019 by the American Academy of Pediatrics.


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