Requirement of ATM in UVA-induced signaling and apoptosis

Yiguo Zhang, Wei-Ya Ma, Akira Kaji, Ann M. Bode, Zigang Dong

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


Solar UVA, but not UVC, reaches the earth's surface and therefore is an important etiological factor for the induction of human skin cancer. ATM kinase is an important regulator of cell survival and cell cycle checkpoints. Here, we observe that UVA, unlike UVC, triggers ATM kinase activity, and the activation may occur through reactive oxygen species produced after irradiation of cells with UVA. We also show that ATM activation is involved in the apoptotic response to UVA but not UVC. Furthermore, we provide evidence that ATM-dependent p53 and c-Jun N-terminal kinase (JNK) pathways are linked to UVA-induced apoptosis. On the other hand, UVC-induced apoptosis occurs through ATR-dependent p53 phosphorylation as well as the JNK pathway. Therefore, these results suggest that ATM, like p53, is involved in the UVA-induced apoptosis to suppress carcinogenesis.

Original languageEnglish (US)
Pages (from-to)3124-3131
Number of pages8
JournalJournal of Biological Chemistry
Issue number5
StatePublished - Feb 1 2002


Dive into the research topics of 'Requirement of ATM in UVA-induced signaling and apoptosis'. Together they form a unique fingerprint.

Cite this