Reproducibility of blood oxygen level-dependent signal changes with end-tidal carbon dioxide alterations

Donald R. Dengel; Nicholas G. Evanoff; Kara L. Marlatt; Justin R. Geijer; Bryon A. Mueller; Kelvin O. Lim

doi:10.1111/cpf.12358

Reproducibility of blood oxygen level-dependent signal changes with end-tidal carbon dioxide alterations

Donald R. Dengel, Nicholas G. Evanoff, Kara L. Marlatt, Justin R. Geijer, Bryon A. Mueller, Kelvin O. Lim

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Hypercapnia has been utilized as a stimulus to elicit changes in cerebral blood flow (CBF). However, in many instances it has been delivered in a non-controlled method that is often difficult to reproduce. The purpose of this study was to examine the within- and between-visit reproducibility of blood oxygen level-dependent (BOLD) signal changes to an iso-oxic square wave alteration in end-tidal carbon dioxide partial pressure (P_etCO₂). Two 3-Tesla (3T) MRI scans were performed on the same visit, with two square wave alterations administered per scan. The protocol was repeated on a separate visit with minimum of 3 days between scanning sessions. P_etCO₂ was altered to stimulate changes in cerebral vascular reactivity (CVR), while P_etO₂ was held constant. Eleven subjects (six females; mean age 26·5 ± 5·7 years) completed the full testing protocol. Excellent within-visit square wave reproducibility (ICC > 0·75) was observed. Similarly, square waves were reproducible between scanning sessions (ICC > 0·7). This study demonstrates BOLD signal changes in response to alterations in P_etCO₂ are reproducible both within- and between-visit MRI scans.

Original language	English (US)
Pages (from-to)	794-798
Number of pages	5
Journal	Clinical Physiology and Functional Imaging
Volume	37
Issue number	6
DOIs	https://doi.org/10.1111/cpf.12358
State	Published - Nov 2017

Bibliographical note

Publisher Copyright:
© 2016 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd

Keywords

cerebral vascular reactivity
hypercapnia
magnetic resonance imaging
vascular function

Publisher link

10.1111/cpf.12358

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5857354

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title = "Reproducibility of blood oxygen level-dependent signal changes with end-tidal carbon dioxide alterations",

abstract = "Hypercapnia has been utilized as a stimulus to elicit changes in cerebral blood flow (CBF). However, in many instances it has been delivered in a non-controlled method that is often difficult to reproduce. The purpose of this study was to examine the within- and between-visit reproducibility of blood oxygen level-dependent (BOLD) signal changes to an iso-oxic square wave alteration in end-tidal carbon dioxide partial pressure (PetCO2). Two 3-Tesla (3T) MRI scans were performed on the same visit, with two square wave alterations administered per scan. The protocol was repeated on a separate visit with minimum of 3 days between scanning sessions. PetCO2 was altered to stimulate changes in cerebral vascular reactivity (CVR), while PetO2 was held constant. Eleven subjects (six females; mean age 26·5 ± 5·7 years) completed the full testing protocol. Excellent within-visit square wave reproducibility (ICC > 0·75) was observed. Similarly, square waves were reproducible between scanning sessions (ICC > 0·7). This study demonstrates BOLD signal changes in response to alterations in PetCO2 are reproducible both within- and between-visit MRI scans.",

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AU - Mueller, Bryon A.

AU - Lim, Kelvin O.

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N2 - Hypercapnia has been utilized as a stimulus to elicit changes in cerebral blood flow (CBF). However, in many instances it has been delivered in a non-controlled method that is often difficult to reproduce. The purpose of this study was to examine the within- and between-visit reproducibility of blood oxygen level-dependent (BOLD) signal changes to an iso-oxic square wave alteration in end-tidal carbon dioxide partial pressure (PetCO2). Two 3-Tesla (3T) MRI scans were performed on the same visit, with two square wave alterations administered per scan. The protocol was repeated on a separate visit with minimum of 3 days between scanning sessions. PetCO2 was altered to stimulate changes in cerebral vascular reactivity (CVR), while PetO2 was held constant. Eleven subjects (six females; mean age 26·5 ± 5·7 years) completed the full testing protocol. Excellent within-visit square wave reproducibility (ICC > 0·75) was observed. Similarly, square waves were reproducible between scanning sessions (ICC > 0·7). This study demonstrates BOLD signal changes in response to alterations in PetCO2 are reproducible both within- and between-visit MRI scans.

AB - Hypercapnia has been utilized as a stimulus to elicit changes in cerebral blood flow (CBF). However, in many instances it has been delivered in a non-controlled method that is often difficult to reproduce. The purpose of this study was to examine the within- and between-visit reproducibility of blood oxygen level-dependent (BOLD) signal changes to an iso-oxic square wave alteration in end-tidal carbon dioxide partial pressure (PetCO2). Two 3-Tesla (3T) MRI scans were performed on the same visit, with two square wave alterations administered per scan. The protocol was repeated on a separate visit with minimum of 3 days between scanning sessions. PetCO2 was altered to stimulate changes in cerebral vascular reactivity (CVR), while PetO2 was held constant. Eleven subjects (six females; mean age 26·5 ± 5·7 years) completed the full testing protocol. Excellent within-visit square wave reproducibility (ICC > 0·75) was observed. Similarly, square waves were reproducible between scanning sessions (ICC > 0·7). This study demonstrates BOLD signal changes in response to alterations in PetCO2 are reproducible both within- and between-visit MRI scans.

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Reproducibility of blood oxygen level-dependent signal changes with end-tidal carbon dioxide alterations

Abstract

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