Replication timing and transcriptional control: Beyond cause and effect - part III

Juan Carlos Rivera-Mulia, David M. Gilbert

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations


DNA replication is essential for faithful transmission of genetic information and is intimately tied to chromosome structure and function. Genome duplication occurs in a defined temporal order known as the replication-timing (RT) program, which is regulated during the cell cycle and development in discrete units referred to as replication domains (RDs). RDs correspond to topologically-associating domains (TADs) and are spatio-temporally compartmentalized in the nucleus. While improvements in experimental tools have begun to reveal glimpses of causality, they have also unveiled complex context-dependent relationships that challenge long recognized correlations of RT to chromatin organization and gene regulation. In particular, RDs/TADs that switch RT during development march to the beat of a different drummer.

Original languageEnglish (US)
Pages (from-to)168-178
Number of pages11
JournalCurrent Opinion in Cell Biology
StatePublished - Jun 1 2016
Externally publishedYes

Bibliographical note

Funding Information:
We would like to thank C. Trevilla-Garcia for critical reading of the manuscript and Karen Reddy for helpful discussions. This work was supported by National Institutes of Health (NIH) grants GM083337 and GM085354 (D.M.G.).

Publisher Copyright:
© 2016 Elsevier Ltd.


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