TY - CHAP
T1 - Replication domains
T2 - Genome compartmentalization into functional replication units
AU - Zhao, Peiyao A.
AU - Rivera-Mulia, Juan Carlos
AU - Gilbert, David M.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - DNA replication occurs in a defined temporal order during S phase, known as the replication timing programme, which is regulated not only during the cell cycle but also during the process of development and differentiation. The units of replication timing regulation, known as replication domains (RDs), frequently comprise several nearly synchronously firing replication origins. Replication domains correspond to topologically associating domains (TADs) mapped by chromatin conformation capture methods and are likely to be the molecular equivalents of replication foci observed using cytogenetic methods. Both TAD and replication foci are considered to be stable structural units of chromosomes, conserved through the cell cycle and development, and accordingly, the boundaries of RDs also appear to be stable in different cell types. During both normal development and progression of disease, distinct cell states are characterized by unique replication timing signatures, with approximately half of genomic RDs switching replication timing between these cell states. Advances in functional genomics provide hope that we can soon gain an understanding of the cause and consequence of the replication timing programme and its myriad correlations with chromatin context and gene regulation.
AB - DNA replication occurs in a defined temporal order during S phase, known as the replication timing programme, which is regulated not only during the cell cycle but also during the process of development and differentiation. The units of replication timing regulation, known as replication domains (RDs), frequently comprise several nearly synchronously firing replication origins. Replication domains correspond to topologically associating domains (TADs) mapped by chromatin conformation capture methods and are likely to be the molecular equivalents of replication foci observed using cytogenetic methods. Both TAD and replication foci are considered to be stable structural units of chromosomes, conserved through the cell cycle and development, and accordingly, the boundaries of RDs also appear to be stable in different cell types. During both normal development and progression of disease, distinct cell states are characterized by unique replication timing signatures, with approximately half of genomic RDs switching replication timing between these cell states. Advances in functional genomics provide hope that we can soon gain an understanding of the cause and consequence of the replication timing programme and its myriad correlations with chromatin context and gene regulation.
KW - Cell cycle
KW - Chromatin
KW - Nucleus
KW - Replication domain (RD)
KW - Replication foci
KW - Replication timing (RT)
KW - Topologically associating domain (TAD)
UR - http://www.scopus.com/inward/record.url?scp=85041039218&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041039218&partnerID=8YFLogxK
U2 - 10.1007/978-981-10-6955-0_11
DO - 10.1007/978-981-10-6955-0_11
M3 - Chapter
C2 - 29357061
AN - SCOPUS:85041039218
T3 - Advances in Experimental Medicine and Biology
SP - 229
EP - 257
BT - Advances in Experimental Medicine and Biology
PB - Springer New York LLC
ER -