Repeated stress dysregulates κ-opioid receptor signaling in the dorsal raphe through a p38α MAPK-dependent mechanism

Keyphrases

• P38 Mitogen-activated Protein Kinase (p38 MAPK) 100%
• Opioid Receptor Signaling 100%
• Dorsal Raphe 100%
• Dorsal Raphe nucleus 100%
• Repeated Stress 100%
• Dynorphin 60%
• Serotonergic 60%
• Serotonergic Neurons 60%
• Stress-induced 40%
• Dysregulation 40%
• Excitability 40%
• Pathological Stress 40%
• Neuronal Excitability 20%
• C57BL 20%
• Opioid Receptors 20%
• G Protein 20%
• Negative Effects 20%
• Induced Activation 20%
• Excision 20%
• Kinase Activation 20%
• Stress State 20%
• Inward Rectifier Potassium Channel 20%
• Tyrosine Phosphorylation 20%
• Site of Action 20%
• Spontaneous Excitatory Postsynaptic Current (sEPSC) 20%
• Presynaptic Inhibition 20%
• Immunoreactivity 20%
• Excitatory Synaptic Transmission 20%
• N-methylation 20%
• Brain Slice 20%
• Selective Agonist 20%
• Kir3.1 20%
• Swim Stress 20%
• Functional Target 20%
• Stress Exposure 20%
• Limbic Brain 20%
• GIRK Currents 20%
• Dysphoric 20%
• Stress Release 20%
• Opioid Receptor System 20%
• Excitatory Transmission 20%
• Adaptive Stress 20%

Neuroscience

• P38 Mitogen-Activated Protein Kinases 100%
• Serotonergic 100%
• Receptor 100%
• Dorsal Raphe Nucleus 83%
• Dynorphin 50%
• Neuronal Excitability 33%
• Behavior (Neuroscience) 16%
• G Protein 16%
• Brain Slice 16%
• Protein Phosphorylation 16%
• Agonist 16%
• Excitability 16%
• Inwardly Rectifying Potassium Channel 16%
• Presynaptic Inhibition 16%
• Synaptic Transmission 16%