Long maternal (LMS) versus brief maternal (BMS) daily separations of rat pups from their mothers have contrasting effects on their adult stress responses and maternal behavior by, respectively, decreasing and increasing licking received from their mothers. We hypothesized that LMS decreases pup-licking in mothers by inducing learned helplessness, creating a depression-like state. We subjected postpartum rats to LMS (3 h), BMS (15 min) or no separation (NMS) on postpartum days 2-14. After weaning, mothers were given a forced swim test (FST). LMS mothers exhibited more immobility and fewer escape attempts than BMS or NMS mothers. These results suggest that LMS induces a depression-like state, which may account for the reductions in maternal behavior seen in LMS mothers. Immobility in the FST is recognized as an animal model of depression. Therefore, LMS may be a model of maternal depression.
Bibliographical noteFunding Information:
This research was supported by PHS Grants MH066217 to MLB and MH61995 to CAP.
Gaynes, B.N., Gavin, N., Meltzer-Brody, S., Lohr, K.N., Swinson, T., Gartlehner, G., Brody, S., Miller, W.C., 2005. Perinatal depression: prevalence, screening accuracy, and screening outcomes. Evidence Report/Technology Assessment No. 119 (Prepared by the TRI-University of North Carolina Evidence-based Practice Center, under Contract No. 290-02-0016. AHRQ Publication No. 05-E006-2. Rockville, MD: Agency for Healthcare Research and Quality.
- Handling effects
- Learned helplessness
- Maternal depression
- Maternal separation