Repairing Large Duodenal Injuries in Dogs by Expanded Polytetrafluoroethylene Patch

Saman Nikeghbalian, Sohrab Atefi, Kourosh Kazemi, Hamed Jalaeian, Naghmeh Roshan, Naser Naderi, Reza Hajizadeh, Nader Tanideh

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Background: One of the most challenging problems in clinical surgery is management of injured duodenum. In this experimental study, we treated large duodenal defects by an expanded polytetrafluoroethylene (ePTFE, Gore-Tex; W.L. Gore, Elkton, MD) soft-tissue patch and compared it with the jejunal serosal patch. Materials and methods: A duodenal defect (about 50% of the total circumference) was created in the second portion of the duodenum in 20 dogs. The effectiveness and gross and histological examinations of the ePTFE patch technique was compared with the jejunal serosal patch. Results: No significant difference was found in early survival rates (90.9% versus 88.9%; P = 0.711). The whole grafted area was covered by neomucosa at the end of the sixth week in all animals with the ePTFE patch. The scar was small; no significant narrowing of lumen was noted and serosal healing was uniformly complete. In histological examination, complete coverage of the ePTFE grafts by neomucosa consisting of columnar epithelium with short villous formations was observed. Conclusion: Use of the ePTFE patch method is easy, reliable, and comparable to the jejunal serosal patch. It can be used in the treatment of large duodenal defects, which cannot be repaired by duodenorraphy.

Original languageEnglish (US)
Pages (from-to)17-21
Number of pages5
JournalJournal of Surgical Research
Issue number1
StatePublished - Jan 2008


  • duodenal defects
  • expanded polytetrafluoroethylene patch
  • repair


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