Repairing brain after stroke: A review on post-ischemic neurogenesis

Charles Wiltrout, Bradley Lang, Yiping Yan, Robert J. Dempsey, Raghu Vemuganti

Research output: Contribution to journalShort survey

142 Scopus citations

Abstract

Stroke is devastating as currently no therapies are available that can prevent stroke-induced neurological dysfunction in humans. With the recent observations that acute insults to adult brain stimulate new neuronal formation in various species of animals, optimism is building for a possible regeneration of stroke-damaged brain. This article reviewed the advances in the understanding of the molecular mechanisms of the various steps of neurogenesis with an emphasis on the endogenous mediators and exogenous promoters of neural progenitor proliferation, migration and survival in the post-ischemic adult brain.

Original languageEnglish (US)
Pages (from-to)1028-1041
Number of pages14
JournalNeurochemistry International
Volume50
Issue number7-8
DOIs
StatePublished - Jun 1 2007

Keywords

  • Cerebral ischemia
  • Growth factors
  • Neural progenitor proliferation
  • Stem cell migration

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