Repair of injured spinal cord using platelet-rich plasma- and endometrial stem cells-loaded chitosan scaffolds

Jafar Ai; Ali Farzin; Sina Zamiri; Mahmoudreza Hadjighassem; Somayeh Ebrahimi-Barough; Armin Ai; Sanam Mohandesnezhad; Ahmad Karampour; Morteza Sagharjoghi Farahani; Arash Goodarzi

doi:10.1080/00914037.2020.1772257

Repair of injured spinal cord using platelet-rich plasma- and endometrial stem cells-loaded chitosan scaffolds

Jafar Ai, Ali Farzin, Sina Zamiri, Mahmoudreza Hadjighassem, Somayeh Ebrahimi-Barough, Armin Ai, Sanam Mohandesnezhad, Ahmad Karampour, Morteza Sagharjoghi Farahani, Arash Goodarzi

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Engineering scaffolds that can not only act as a vehicle for stem cell delivery but also support axon regeneration, may significantly improve the treatment outcome of spinal cord injury (SCI). In this study, we developed chitosan scaffold containing human endometrial stem cells (hEnSCs) and platelet-rich plasma (PRP) to provide a controlled environment for facilitating cell ingrowth and differentiation and also to persuade axon nervous tissue repair. The results showed that 80 µL PRP-loaded chitosan scaffold has excellent hEnSCs viability and can promote the regeneration of nerve fibers and angiogenesis and prevent the formation of scar tissue in the repair of SCI.

Original language	English (US)
Pages (from-to)	1002-1011
Number of pages	10
Journal	International Journal of Polymeric Materials and Polymeric Biomaterials
Volume	70
Issue number	14
DOIs	https://doi.org/10.1080/00914037.2020.1772257
State	Published - 2021
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2020 Taylor & Francis Group, LLC.

Keywords

Chitosan scaffold
human endometrial stem cells
platelet-rich plasma
spinal cord injury

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10.1080/00914037.2020.1772257

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Ai, J., Farzin, A., Zamiri, S., Hadjighassem, M., Ebrahimi-Barough, S., Ai, A., Mohandesnezhad, S., Karampour, A., Sagharjoghi Farahani, M., & Goodarzi, A. (2021). Repair of injured spinal cord using platelet-rich plasma- and endometrial stem cells-loaded chitosan scaffolds. International Journal of Polymeric Materials and Polymeric Biomaterials, 70(14), 1002-1011. https://doi.org/10.1080/00914037.2020.1772257

Ai, J, Farzin, A, Zamiri, S, Hadjighassem, M, Ebrahimi-Barough, S, Ai, A, Mohandesnezhad, S, Karampour, A, Sagharjoghi Farahani, M & Goodarzi, A 2021, 'Repair of injured spinal cord using platelet-rich plasma- and endometrial stem cells-loaded chitosan scaffolds', International Journal of Polymeric Materials and Polymeric Biomaterials, vol. 70, no. 14, pp. 1002-1011. https://doi.org/10.1080/00914037.2020.1772257

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abstract = "Engineering scaffolds that can not only act as a vehicle for stem cell delivery but also support axon regeneration, may significantly improve the treatment outcome of spinal cord injury (SCI). In this study, we developed chitosan scaffold containing human endometrial stem cells (hEnSCs) and platelet-rich plasma (PRP) to provide a controlled environment for facilitating cell ingrowth and differentiation and also to persuade axon nervous tissue repair. The results showed that 80 µL PRP-loaded chitosan scaffold has excellent hEnSCs viability and can promote the regeneration of nerve fibers and angiogenesis and prevent the formation of scar tissue in the repair of SCI.",

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year = "2021",

doi = "10.1080/00914037.2020.1772257",

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T1 - Repair of injured spinal cord using platelet-rich plasma- and endometrial stem cells-loaded chitosan scaffolds

AU - Ai, Jafar

AU - Farzin, Ali

AU - Zamiri, Sina

AU - Hadjighassem, Mahmoudreza

AU - Ebrahimi-Barough, Somayeh

AU - Ai, Armin

AU - Mohandesnezhad, Sanam

AU - Karampour, Ahmad

AU - Sagharjoghi Farahani, Morteza

AU - Goodarzi, Arash

PY - 2021

Y1 - 2021

N2 - Engineering scaffolds that can not only act as a vehicle for stem cell delivery but also support axon regeneration, may significantly improve the treatment outcome of spinal cord injury (SCI). In this study, we developed chitosan scaffold containing human endometrial stem cells (hEnSCs) and platelet-rich plasma (PRP) to provide a controlled environment for facilitating cell ingrowth and differentiation and also to persuade axon nervous tissue repair. The results showed that 80 µL PRP-loaded chitosan scaffold has excellent hEnSCs viability and can promote the regeneration of nerve fibers and angiogenesis and prevent the formation of scar tissue in the repair of SCI.

AB - Engineering scaffolds that can not only act as a vehicle for stem cell delivery but also support axon regeneration, may significantly improve the treatment outcome of spinal cord injury (SCI). In this study, we developed chitosan scaffold containing human endometrial stem cells (hEnSCs) and platelet-rich plasma (PRP) to provide a controlled environment for facilitating cell ingrowth and differentiation and also to persuade axon nervous tissue repair. The results showed that 80 µL PRP-loaded chitosan scaffold has excellent hEnSCs viability and can promote the regeneration of nerve fibers and angiogenesis and prevent the formation of scar tissue in the repair of SCI.

KW - Chitosan scaffold

KW - human endometrial stem cells

KW - platelet-rich plasma

KW - spinal cord injury

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Repair of injured spinal cord using platelet-rich plasma- and endometrial stem cells-loaded chitosan scaffolds

Abstract

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