Renin and angiotensinogen gene expression in experimental diabetes mellitus

Ricardo Correa-Rotter, Thomas H. Hostetter, Mark E Rosenberg

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

The renin-angiotensin system may play a role in the initiation and progression of diabetic kidney disease. In this study, the local intrarenal renin-angiotensin system was examined in streptozotocin-treated rats maintained moderately hyperglycemic by daily low-dose insulin injection. Four weeks after induction of diabetes, plasma renin activity was significantly lower in the diabetic compared to a non-diabetic control group (diabetes: 2.30 ± 0.30 vs. control: 6.93 ± 1.36 ng Al/ml/hr; P < 0.01). Renal tissue renin content (diabetes: 1.81 ± 0.46 vs. control: 2.05 ± 0.27 μg Al/mg protein/hr; P < 0.05) and renal renin mRNA (diabetes: 2.32 ± 0.16 vs. control: 1.89 ± 0.12 pg/μg RNA; P = NS) were not different between diabetic and control rats. Renal and liver angiotensinogen mRNA were lower in the diabetic group. Glomerular renin mRNA was not different between the diabetic and sham group. The dissociation between systemic renin activity (a decrease), and in renal renin content or mRNA in the diabetic rats (no change), suggests a post-translational alteration in renin processing and/or renin secretion.

Original languageEnglish (US)
Pages (from-to)796-804
Number of pages9
JournalKidney international
Volume41
Issue number4
DOIs
StatePublished - Jan 1 1992

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Angiotensinogen
Experimental Diabetes Mellitus
Renin
Gene Expression
Kidney
Messenger RNA
Renin-Angiotensin System
Diabetic Nephropathies
Streptozocin
RNA
Insulin
Control Groups
Injections
Liver

Cite this

Renin and angiotensinogen gene expression in experimental diabetes mellitus. / Correa-Rotter, Ricardo; Hostetter, Thomas H.; Rosenberg, Mark E.

In: Kidney international, Vol. 41, No. 4, 01.01.1992, p. 796-804.

Research output: Contribution to journalArticle

Correa-Rotter, Ricardo ; Hostetter, Thomas H. ; Rosenberg, Mark E. / Renin and angiotensinogen gene expression in experimental diabetes mellitus. In: Kidney international. 1992 ; Vol. 41, No. 4. pp. 796-804.
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