Renal transplantation in patients with alport syndrome: Patient selection, outcomes, and donor evaluation

Clifford E. Kashtan

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Alport syndrome is an inherited disorder of basement membrane collagen IV that frequently results in end-stage renal disease. Patients with Alport syndrome who undergo renal transplantation have generally excellent outcomes. Posttransplant antiglomerular basement membrane nephritis is a rare complication of renal transplantation for Alport syndrome. Because Alport syndrome is a genetic disorder, potential related donors must be carefully evaluated in order to minimize harm.

Original languageEnglish (US)
Pages (from-to)267-270
Number of pages4
JournalInternational Journal of Nephrology and Renovascular Disease
Volume11
DOIs
StatePublished - 2018

Bibliographical note

Funding Information:
NCT00481130), which receives financial support from the Alport Syndrome Foundation (alportsyndrome.org) and the Schuman and Pedersen families. Dr Kashtan is a site investigator for the CARDINAL trial (NCT03019185) sponsored by Reata Pharmaceuticals, Inc. and the HERA trial (NCT02855268) sponsored by Regulus Therapeutics, Inc. Dr Kashtan has also recently received research support from the Novartis Institute for Biomedical Research (NCT03074357).

Keywords

  • Alport syndrome
  • Collagen IV
  • Kidney transplantation
  • Posttransplant anti-GBM Nephritis

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