Renal transplantation in patients with Alport syndrome

Clifford E. Kashtan

Research output: Contribution to journalReview articlepeer-review

88 Scopus citations


For pediatric kidney transplant physicians, two aspects of Alport syndrome set the disease apart from other causes of terminal renal failure. First, an understanding of the genetics of Alport syndrome is needed to make appropriate decisions regarding potential related kidney donors to Alport patients requiring renal transplantation. Second, renal transplantation for Alport syndrome may be complicated by post-transplant anti-GBM nephritis, a problem that is nearly unique to this disease. This review discusses these aspects of Alport syndrome and attempts to provide rational recommendations for clinicians.

Original languageEnglish (US)
Pages (from-to)651-657
Number of pages7
JournalPediatric transplantation
Issue number6
StatePublished - Sep 2006


  • Alport syndrome
  • Anti-GBM nephritis
  • Renal transplantation
  • Type IV collagen


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