Renal dysfunction accounts for the dose limiting toxicity of DT₃₉₀anti-CD3sFv, a potential new recombinant anti-GVHD immunotoxin

Keyphrases

• Dose-limiting Toxicity 100%
• Recombinant 100%
• Immunotoxin 100%
• Renal Dysfunction 100%
• Kidney 66%
• Complementary DNA (cDNA) 66%
• DT390 66%
• Histology 33%
• T Cells 33%
• Liver 33%
• Maximum Tolerated Dose 33%
• Genetic Modification 33%
• Allogeneic 33%
• Fusion Protein 33%
• Severe Combined Immunodeficiency 33%
• Highly Selective 33%
• Serum Levels 33%
• Diphtheria Toxin 33%
• Donor T Cell 33%
• Blood Urea Nitrogen 33%
• Equivalent Dose 33%
• Hybrid Genes 33%
• Reduced Toxicity 33%
• Toxic Injury 33%
• Renal Toxicity 33%
• Single-chain Fv 33%
• D-T Fusion 33%
• Recombinant Fusion 33%
• CD3E 33%
• In Vivo Applications 33%
• Urea Creatinine 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Graft Versus Host Reaction 100%
• Recombinant 100%
• Immunotoxin 100%
• Complementary DNA 66%
• Toxic Injury 33%
• Diphtheria Toxin 33%
• Murine 33%
• Nephrotoxicity 33%
• Creatinine 33%
• Single Chain Fragment Variable Antibody 33%
• Chimeric Protein 33%
• CD3 Antigen 33%
• Severe Combined Immunodeficiency 33%
• Maximum Tolerated Dose 33%
• Ureaplasma 33%
• Nitrogen 33%

Immunology and Microbiology

• Graft-Versus-Host Disease 100%
• Immunotoxin 100%
• T Cell 66%
• Severe Combined Immunodeficiency 33%
• DNA Modification 33%
• Blood Level 33%
• Murine 33%
• Hybrid Gene 33%
• Single-Chain Variable Fragment 33%
• Urea Nitrogen Blood Level 33%
• Maximum Tolerated Dose 33%
• CD3 Antigen 33%