Renal adaptation during hibernation

Alkesh Jani, Sandra L. Martin, Swati Jain, Daniel Keys, Charles L. Edelstein

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


Hibernators periodically undergo profound physiological changes including dramatic reductions in metabolic, heart, and respiratory rates and core body temperature. This review discusses the effect of hypoperfusion and hypothermia observed during hibernation on glomerular filtration and renal plasma flow, as well as specific adaptations in renal architecture, vasculature, the renin-angiotensin system, and upregulation of possible protective mechanisms during the extreme conditions endured by hibernating mammals. Understanding the mechanisms of protection against organ injury during hibernation may provide insights into potential therapies for organ injury during cold storage and reimplantation during transplantation.

Original languageEnglish (US)
Pages (from-to)F1521-F1532
JournalAmerican Journal of Physiology - Renal Physiology
Issue number11
StatePublished - Dec 1 2013


  • Electrolytes
  • Hibernation
  • Kidney
  • Metabolism
  • Torpor


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