Remote Tumor Effects on Lactic Dehydrogenase of Mouse Muscle Fibers with Different Glycolytic-Oxidative Metabolic Potentials (41244)

G. A. Ibrahim, B. A. Zweber, Athanasios Theologides

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

The total lactic dehydrogenase (LD) activity and the isoenzyme pattern were studied in muscles of mice during the progressive growth of a distally transplanted methylcholanthrene-induced tumor. The thigh muscles as a group (a mixture of fibers with different oxidative-glycolytic metabolic potentials), the gastrocnemius muscle (primarily glycolytic), the soleus muscle (predominantly oxidative), the heart (purely oxidative), and the diaphragm (primarily oxidative) were evaluated. The total LD activity increased in muscles with a high glycolytic metabolic potential. In such muscles a significant increase of the muscle type and a significant decrease of the heart type of LD were observed. After 3 weeks of tumor growth the tumor was resected, and the LD activity and isoenzyme distribution returned toward normal values 2 weeks later.

Original languageEnglish (US)
Pages (from-to)119-122
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Volume168
Issue number1
DOIs
StatePublished - Oct 1981

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