Abstract
The total lactic dehydrogenase (LD) activity and the isoenzyme pattern were studied in muscles of mice during the progressive growth of a distally transplanted methylcholanthrene-induced tumor. The thigh muscles as a group (a mixture of fibers with different oxidative-glycolytic metabolic potentials), the gastrocnemius muscle (primarily glycolytic), the soleus muscle (predominantly oxidative), the heart (purely oxidative), and the diaphragm (primarily oxidative) were evaluated. The total LD activity increased in muscles with a high glycolytic metabolic potential. In such muscles a significant increase of the muscle type and a significant decrease of the heart type of LD were observed. After 3 weeks of tumor growth the tumor was resected, and the LD activity and isoenzyme distribution returned toward normal values 2 weeks later.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 119-122 |
| Number of pages | 4 |
| Journal | Proceedings of the Society for Experimental Biology and Medicine |
| Volume | 168 |
| Issue number | 1 |
| DOIs | |
| State | Published - Oct 1981 |
Bibliographical note
Funding Information:This study was supported by a grant from the Minnesota Masonic Memorial Cancer Research Fund and in part by Grant GOO-800-3033 from the National Institute of Handicapped Research, Department of Education, Washington, D.C., for the University of Minnesota Medical Rehabilitation Research and Training Center.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.