REM sleep without atonia is associated with increased rigidity in patients with mild to moderate Parkinson's disease

Maria E. Linn-Evans; Matthew N. Petrucci; Sommer L. Amundsen Huffmaster; Jae Woo Chung; Paul J. Tuite; Michael J. Howell; Aleksandar Videnovic; Colum D. MacKinnon

doi:10.1016/j.clinph.2020.04.017

REM sleep without atonia is associated with increased rigidity in patients with mild to moderate Parkinson's disease

Maria E. Linn-Evans, Matthew N. Petrucci, Sommer L. Amundsen Huffmaster, Jae Woo Chung, Paul J. Tuite, Michael J. Howell, Aleksandar Videnovic, Colum D. MacKinnon

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Objective: Increased muscle activity during rapid eye movement (REM) sleep (i.e. REM sleep without atonia) is common in people with Parkinson's disease (PD). This study tested the hypotheses that people with PD and REM sleep without atonia (RSWA) would present with more severe and symmetric rigidity compared to individuals with PD without RSWA and age-matched controls. Methods: Sixty-one individuals participated in this study (41 PD, 20 controls). An overnight sleep study was used to classify participants with PD as having either elevated (PD-RSWA+) or normal muscle activity (PD-RSWA−) during REM sleep. Quantitative measures of rigidity were obtained using a robotic manipulandum that passively pronated and supinated the forearm. Results: Quantitative measures of forearm rigidity were significantly higher in the PD-RSWA+ group compared to the control group. Rigidity was significantly more asymmetric between limbs in the PD-RSWA− group compared with controls, while there was no significant difference in symmetry between the control and PD-RSWA+ groups. Conclusion: In people with mild to moderate PD, RSWA is associated with an increased and more symmetric presentation of upper limb rigidity. Significance: Dysfunction of brainstem systems that control muscle tone during REM sleep may contribute to increased rigidity during wakefulness in people with PD.

Original language	English (US)
Pages (from-to)	2008-2016
Number of pages	9
Journal	Clinical Neurophysiology
Volume	131
Issue number	8
DOIs	https://doi.org/10.1016/j.clinph.2020.04.017
State	Published - Aug 2020

Bibliographical note

Funding Information:
We would like to thank our research volunteers for their participation in this study, Joshua De Kam for his role in coordinating this research, Devin O’Connell and Minwoo Kim for assistance in data collection and administration, Drs. Martha Nance, Julia Johnson, Daniel Kuyper, and Sotirios Parashos for referring volunteers to our study, and Dr. Lynn Eberly for statistical consultation. This work was supported by the National Institutes of Health grants R01 NS070264 , R01 NS088670 , P50 NS09857 , T32 GM008471 , 8UL1TR000114-02 and UL1TR000114 , National Science Foundation fellowship DGE - 1734815 , the Parkinson Study Group, the Parkinson's Disease Foundation, the Wallin Neuroscience Discovery Fund , and MnDRIVE Research Fellowships in Neuromodulation .

Publisher Copyright:
© 2020 International Federation of Clinical Neurophysiology

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

Keywords

Parkinson's disease
REM sleep behavior disorder
REM sleep without atonia
Rigidity

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REM sleep without atonia is associated with increased rigidity in patients with mild to moderate Parkinson's disease. / Linn-Evans, Maria E.; Petrucci, Matthew N.; Amundsen Huffmaster, Sommer L.; Chung, Jae Woo; Tuite, Paul J.; Howell, Michael J.; Videnovic, Aleksandar; MacKinnon, Colum D.

In: Clinical Neurophysiology, Vol. 131, No. 8, 08.2020, p. 2008-2016.

Research output: Contribution to journal › Article › peer-review

Linn-Evans, Maria E. ; Petrucci, Matthew N. ; Amundsen Huffmaster, Sommer L. ; Chung, Jae Woo ; Tuite, Paul J. ; Howell, Michael J. ; Videnovic, Aleksandar ; MacKinnon, Colum D. / REM sleep without atonia is associated with increased rigidity in patients with mild to moderate Parkinson's disease. In: Clinical Neurophysiology. 2020 ; Vol. 131, No. 8. pp. 2008-2016.

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abstract = "Objective: Increased muscle activity during rapid eye movement (REM) sleep (i.e. REM sleep without atonia) is common in people with Parkinson's disease (PD). This study tested the hypotheses that people with PD and REM sleep without atonia (RSWA) would present with more severe and symmetric rigidity compared to individuals with PD without RSWA and age-matched controls. Methods: Sixty-one individuals participated in this study (41 PD, 20 controls). An overnight sleep study was used to classify participants with PD as having either elevated (PD-RSWA+) or normal muscle activity (PD-RSWA−) during REM sleep. Quantitative measures of rigidity were obtained using a robotic manipulandum that passively pronated and supinated the forearm. Results: Quantitative measures of forearm rigidity were significantly higher in the PD-RSWA+ group compared to the control group. Rigidity was significantly more asymmetric between limbs in the PD-RSWA− group compared with controls, while there was no significant difference in symmetry between the control and PD-RSWA+ groups. Conclusion: In people with mild to moderate PD, RSWA is associated with an increased and more symmetric presentation of upper limb rigidity. Significance: Dysfunction of brainstem systems that control muscle tone during REM sleep may contribute to increased rigidity during wakefulness in people with PD.",

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author = "Linn-Evans, {Maria E.} and Petrucci, {Matthew N.} and {Amundsen Huffmaster}, {Sommer L.} and Chung, {Jae Woo} and Tuite, {Paul J.} and Howell, {Michael J.} and Aleksandar Videnovic and MacKinnon, {Colum D.}",

note = "Funding Information: We would like to thank our research volunteers for their participation in this study, Joshua De Kam for his role in coordinating this research, Devin O{\textquoteright}Connell and Minwoo Kim for assistance in data collection and administration, Drs. Martha Nance, Julia Johnson, Daniel Kuyper, and Sotirios Parashos for referring volunteers to our study, and Dr. Lynn Eberly for statistical consultation. This work was supported by the National Institutes of Health grants R01 NS070264 , R01 NS088670 , P50 NS09857 , T32 GM008471 , 8UL1TR000114-02 and UL1TR000114 , National Science Foundation fellowship DGE - 1734815 , the Parkinson Study Group, the Parkinson's Disease Foundation, the Wallin Neuroscience Discovery Fund , and MnDRIVE Research Fellowships in Neuromodulation . Publisher Copyright: {\textcopyright} 2020 International Federation of Clinical Neurophysiology Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

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T1 - REM sleep without atonia is associated with increased rigidity in patients with mild to moderate Parkinson's disease

AU - Linn-Evans, Maria E.

AU - Petrucci, Matthew N.

AU - Amundsen Huffmaster, Sommer L.

AU - Chung, Jae Woo

AU - Tuite, Paul J.

AU - Howell, Michael J.

AU - Videnovic, Aleksandar

AU - MacKinnon, Colum D.

N1 - Funding Information: We would like to thank our research volunteers for their participation in this study, Joshua De Kam for his role in coordinating this research, Devin O’Connell and Minwoo Kim for assistance in data collection and administration, Drs. Martha Nance, Julia Johnson, Daniel Kuyper, and Sotirios Parashos for referring volunteers to our study, and Dr. Lynn Eberly for statistical consultation. This work was supported by the National Institutes of Health grants R01 NS070264 , R01 NS088670 , P50 NS09857 , T32 GM008471 , 8UL1TR000114-02 and UL1TR000114 , National Science Foundation fellowship DGE - 1734815 , the Parkinson Study Group, the Parkinson's Disease Foundation, the Wallin Neuroscience Discovery Fund , and MnDRIVE Research Fellowships in Neuromodulation . Publisher Copyright: © 2020 International Federation of Clinical Neurophysiology Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/8

Y1 - 2020/8

N2 - Objective: Increased muscle activity during rapid eye movement (REM) sleep (i.e. REM sleep without atonia) is common in people with Parkinson's disease (PD). This study tested the hypotheses that people with PD and REM sleep without atonia (RSWA) would present with more severe and symmetric rigidity compared to individuals with PD without RSWA and age-matched controls. Methods: Sixty-one individuals participated in this study (41 PD, 20 controls). An overnight sleep study was used to classify participants with PD as having either elevated (PD-RSWA+) or normal muscle activity (PD-RSWA−) during REM sleep. Quantitative measures of rigidity were obtained using a robotic manipulandum that passively pronated and supinated the forearm. Results: Quantitative measures of forearm rigidity were significantly higher in the PD-RSWA+ group compared to the control group. Rigidity was significantly more asymmetric between limbs in the PD-RSWA− group compared with controls, while there was no significant difference in symmetry between the control and PD-RSWA+ groups. Conclusion: In people with mild to moderate PD, RSWA is associated with an increased and more symmetric presentation of upper limb rigidity. Significance: Dysfunction of brainstem systems that control muscle tone during REM sleep may contribute to increased rigidity during wakefulness in people with PD.

AB - Objective: Increased muscle activity during rapid eye movement (REM) sleep (i.e. REM sleep without atonia) is common in people with Parkinson's disease (PD). This study tested the hypotheses that people with PD and REM sleep without atonia (RSWA) would present with more severe and symmetric rigidity compared to individuals with PD without RSWA and age-matched controls. Methods: Sixty-one individuals participated in this study (41 PD, 20 controls). An overnight sleep study was used to classify participants with PD as having either elevated (PD-RSWA+) or normal muscle activity (PD-RSWA−) during REM sleep. Quantitative measures of rigidity were obtained using a robotic manipulandum that passively pronated and supinated the forearm. Results: Quantitative measures of forearm rigidity were significantly higher in the PD-RSWA+ group compared to the control group. Rigidity was significantly more asymmetric between limbs in the PD-RSWA− group compared with controls, while there was no significant difference in symmetry between the control and PD-RSWA+ groups. Conclusion: In people with mild to moderate PD, RSWA is associated with an increased and more symmetric presentation of upper limb rigidity. Significance: Dysfunction of brainstem systems that control muscle tone during REM sleep may contribute to increased rigidity during wakefulness in people with PD.

KW - Parkinson's disease

KW - REM sleep behavior disorder

KW - REM sleep without atonia

KW - Rigidity

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REM sleep without atonia is associated with increased rigidity in patients with mild to moderate Parkinson's disease

Abstract

Bibliographical note

Keywords

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