Relief of upper airway obstruction with hypoglossal nerve stimulation in the canine

George S. Goding, David W. Eisele, Roy Testerman, Philip L. Smith, Karen Roertgen, Alan R. Schwartz

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Hypoglossal nerve stimulation was investigated as a method to relieve an induced upper airway obstruction. Six dogs were implanted with a cuff electrode applied to each hypoglossal nerve and a pulse generator. After 4 weeks, the hypoglossal nerve was stimulated (50% duty cycle) for up to 8 weeks. At 12 weeks a double tracheotomy was placed, with a negative pressure intermittently applied to the upper limb, simulating inspiratory airway pressure. Unilateral hypoglossal nerve stimulation improved peak upper airway flow from an average of 0.1 L/s to 1.6 L/s (P = 0.0001). Seventy-seven percent of the maximum possible flow (explanted tracheotomy tube) was obtained with unilateral stimulation. Histopathological evaluation revealed no nerve damage secondary to chronic stimulation. This study provides support for clinical trials of hypoglossal stimulation for obstructive sleep apnea.

Original languageEnglish (US)
Pages (from-to)162-169
Number of pages8
JournalLaryngoscope
Volume108
Issue number2
DOIs
StatePublished - Feb 1 1998

Fingerprint Dive into the research topics of 'Relief of upper airway obstruction with hypoglossal nerve stimulation in the canine'. Together they form a unique fingerprint.

Cite this