Relief of itch by scratching

State-dependent inhibition of primate spinothalamic tract neurons

Steve Davidson, Xijing Zhang, Sergey Khasabov, Donald A Simone, Glenn J Giesler

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

Itch is relieved by scratching, but the neural mechanisms that are responsible for this are unknown. Spinothalamic tract (STT) neurons respond to itch-producing agents and transmit pruritic information to the brain. We observed that scratching the cutaneous receptive field of primate STT neurons produced inhibition during histamine-evoked activity but not during spontaneous activity or activity evoked by a painful stimulus, suggesting that scratching inhibits the transmission of itch in the spinal cord in a state-dependent manner.

Original languageEnglish (US)
Pages (from-to)544-546
Number of pages3
JournalNature Neuroscience
Volume12
Issue number5
DOIs
StatePublished - May 1 2009

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Spinothalamic Tracts
Primates
Neurons
Histamine
Spinal Cord
Skin
Brain

Cite this

Relief of itch by scratching : State-dependent inhibition of primate spinothalamic tract neurons. / Davidson, Steve; Zhang, Xijing; Khasabov, Sergey; Simone, Donald A; Giesler, Glenn J.

In: Nature Neuroscience, Vol. 12, No. 5, 01.05.2009, p. 544-546.

Research output: Contribution to journalArticle

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