TY - JOUR
T1 - Reliability of single urine and serum samples for estimation of 24-hour urinary uric acid excretion in six healthy beagles.
AU - Bartges, J. W.
AU - Osborne, Carl A
AU - Felice, L. J.
AU - Unger, L. K.
AU - Bird, K. A.
AU - Koehler, L. A.
AU - Chen, M.
PY - 1994/4
Y1 - 1994/4
N2 - Urine uric acid-to-urine creatinine ratios (UUA:UC), urine uric acid concentrations, urine uric acid concentrations corrected for glomerular filtration rate, and urinary uric acid fractional excretions were compared with 24-hour urinary uric acid excretions measured in 6 healthy adult female Beagles. Comparisons, using correlation analysis, were made when dogs consumed a 10.4% protein (dry weight), casein-based diet and a 31.4% protein (dry weight), meat-based diet. The UUA:UC, urine uric acid concentrations corrected for glomerular filtration rate, and urinary uric acid fractional excretions were not reliable estimates of 24-hour urinary uric acid excretions during consumption of either diet. Urine uric acid concentrations in samples collected 2, 4, 6, and 24 hours after initiation of collection correlated with 24-hour urinary uric acid excretions when dogs consumed the casein-based diet; correlation was not found at any time interval when dogs consumed the meat-based diet. Therefore, determination of 24-hour urinary uric acid excretion is recommended because UUA:UC are unreliable.
AB - Urine uric acid-to-urine creatinine ratios (UUA:UC), urine uric acid concentrations, urine uric acid concentrations corrected for glomerular filtration rate, and urinary uric acid fractional excretions were compared with 24-hour urinary uric acid excretions measured in 6 healthy adult female Beagles. Comparisons, using correlation analysis, were made when dogs consumed a 10.4% protein (dry weight), casein-based diet and a 31.4% protein (dry weight), meat-based diet. The UUA:UC, urine uric acid concentrations corrected for glomerular filtration rate, and urinary uric acid fractional excretions were not reliable estimates of 24-hour urinary uric acid excretions during consumption of either diet. Urine uric acid concentrations in samples collected 2, 4, 6, and 24 hours after initiation of collection correlated with 24-hour urinary uric acid excretions when dogs consumed the casein-based diet; correlation was not found at any time interval when dogs consumed the meat-based diet. Therefore, determination of 24-hour urinary uric acid excretion is recommended because UUA:UC are unreliable.
UR - http://www.scopus.com/inward/record.url?scp=0028411320&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028411320&partnerID=8YFLogxK
M3 - Article
C2 - 8017691
AN - SCOPUS:0028411320
SN - 0002-9645
VL - 55
SP - 472
EP - 476
JO - American journal of veterinary research
JF - American journal of veterinary research
IS - 4
ER -