Reliability of single urine and serum samples for estimation of 24-hour urinary uric acid excretion in six healthy beagles.

J. W. Bartges, Carl A Osborne, L. J. Felice, L. K. Unger, K. A. Bird, L. A. Koehler, M. Chen

Research output: Contribution to journalArticle

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Abstract

Urine uric acid-to-urine creatinine ratios (UUA:UC), urine uric acid concentrations, urine uric acid concentrations corrected for glomerular filtration rate, and urinary uric acid fractional excretions were compared with 24-hour urinary uric acid excretions measured in 6 healthy adult female Beagles. Comparisons, using correlation analysis, were made when dogs consumed a 10.4% protein (dry weight), casein-based diet and a 31.4% protein (dry weight), meat-based diet. The UUA:UC, urine uric acid concentrations corrected for glomerular filtration rate, and urinary uric acid fractional excretions were not reliable estimates of 24-hour urinary uric acid excretions during consumption of either diet. Urine uric acid concentrations in samples collected 2, 4, 6, and 24 hours after initiation of collection correlated with 24-hour urinary uric acid excretions when dogs consumed the casein-based diet; correlation was not found at any time interval when dogs consumed the meat-based diet. Therefore, determination of 24-hour urinary uric acid excretion is recommended because UUA:UC are unreliable.

Original languageEnglish (US)
Pages (from-to)472-476
Number of pages5
JournalAmerican journal of veterinary research
Volume55
Issue number4
StatePublished - Apr 1994

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    Bartges, J. W., Osborne, C. A., Felice, L. J., Unger, L. K., Bird, K. A., Koehler, L. A., & Chen, M. (1994). Reliability of single urine and serum samples for estimation of 24-hour urinary uric acid excretion in six healthy beagles. American journal of veterinary research, 55(4), 472-476.