Reliability of carnitine concentrations measured in single postprandial urine samples from dogs

Sherry Sanderson, Carl Osborne, Jody P Lulich, Mary Ella M Pierpont, Kathy Gross, Phillip Ogburn, Lori Koehler, Marileda Carvalho

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Objective - To evaluate the reliability of urine carnitine concentrations measured in single postprandial samples, compared with carnitine concentrations measured in 24-hour urine samples. Animals - 19 healthy Beagles. Procedure - After emptying the urinary bladder by catheterization, dogs were fed a canned canine maintenance diet. Approximately 8 hours later, urine, plasma, and serum samples were obtained for determination of urinary carnitine fractional excretion and urine carnitine-to-creatinine concentration ratio. Results were compared with 24-hour urinary carnitine excretion rate. Results - Fractional excretion of carnitine and urine carnitine-to-creatinine ratios correlated poorly with 24-hour urinary carnitine excretion. Conclusion - Determination of 24-hour urinary carnitine excretion is recommended to measure urine carnitine concentrations in dogs.

Original languageEnglish (US)
Pages (from-to)1185-1188
Number of pages4
JournalAmerican journal of veterinary research
Volume57
Issue number8
StatePublished - Aug 1 1996

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