Relevance of miR-223 as Potential Diagnostic and Prognostic Markers in Cancer

Faisal Aziz, Abhijit Chakraborty, Imran Khan, Josh Monts

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


In 1993, the discovery of microRNAs in Caenorhabditis elegans (C. elegans) altered the paradigmatic view of RNA biology and post-transcriptional gene regulation. Further study revealed the role of microRNAs in disease development and progression. In particular, this review highlights microRNA-223 (miR-223 or miRNA-223) expression in malignant neoplastic dis-orders. miR-223 expression controls aspects of hematopoiesis and apoptosis, and cell prolifera-tion, migration, and invasion. miR-223 regulates a number of gene targets, including cytoplasmic activation/proliferation-associated protein-1 (Caprin-1), insulin-like growth factor-1 receptor (IGF-1R), and other cell proliferation-and cell cycle-associated genes. Several studies have proposed miR-223 as a novel biomarker for early cancer diagnosis. Here, we emphasize miR-223 s role in the development and progression of cancer.

Original languageEnglish (US)
Article number249
Issue number2
StatePublished - Feb 2022

Bibliographical note

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.


  • Biomarker
  • Carcinogenesis
  • Cell proliferation
  • Circulating miRNA
  • Diagnosis
  • MiR-223

PubMed: MeSH publication types

  • Journal Article
  • Review


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