Relationship of serum uric acid to 4-year incidence of hypertension and blood pressure change in a Chinese population

H. Zhang, Y. Li, S. Tao, B. Zhou, A. R. Folsom, S. Irving, J. Stamler

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Background: Studies have reported a positive relation between serum uric acid and incident cardiovascular diseases. Few prospective studies have assessed the relation of uric acid with hypertension incidence and blood pressure change. Design and Methods: Prospective epidemiological study of nonhypertensive northern Chinese men and women aged 35 - 59 in 1984 and re-examined in 1988. Results: Of 1480 people with systolic blood pressure < 135, diastolic blood pressure < 85 mmHg, and not using antihypertensive drugs in 1984, the 4-year incidence of hypertension was 13.1% and was generally higher with successively higher serum uric acid quartiles (P < 0.05). There were significant positive correlations of uric acid in 1984 with diastolic blood pressure and body mass index and with systolic blood pressure and age (women only), and in 1988 with systolic blood pressure, diastolic blood pressure, and body mass index. In multiple logistic regression analyses including baseline uric acid and age, a higher uric acid of one standard deviation (1.14 mg/dL) was associated with greater risk of hypertension for men (OR 1.40, 95% CI: 1.12-1.74) but not for women. With body mass index, alcohol, smoking, and baseline systolic blood pressure added to the model, this uric acid-hypertension relation for men remained statistically significant (OR = 1.33, 95% CI = 1.05-1.69). This association was observed primarily among alcohol-drinking men. In multiple linear regression there was a significant positive relation of baseline uric acid, age, body mass index, smoking status, and weight change to 4-year change in systolic blood pressure for men. Conclusions: These data indicate that independent of body mass index, smoking, and alcohol intake, serum uric acid is a modest risk factor for blood pressure rise and hypertension incidence for men, but not for women.

Original languageEnglish (US)
Pages (from-to)221-228
Number of pages8
JournalCVD Prevention
Issue number3
StatePublished - 2000


  • Blood pressure
  • China
  • Cohort
  • Hypertension
  • Population study
  • Serum uric acid


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