Relationship of renal size to nephropathy in Type 1 (insulin-dependent) diabetes

E. N. Ellis; Michael W Steffes; F. C. Goetz; D. E.R. Sutherland; Michael Mauer

doi:10.1007/BF00276993

Relationship of renal size to nephropathy in Type 1 (insulin-dependent) diabetes

E. N. Ellis
, Michael W Steffes
, F. C. Goetz
, D. E.R. Sutherland
, Michael Mauer

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Thirty-five patients with Type 1 (insulin-dependent) diabetes mellitus and 90 normal subjects had renal size (renal area index) determined by X-ray and also had examination of renal biopsies by light and electron microscopy. Renal area index of 206±32 cm²/1.73 m² (mean±SD) in the Type 1 diabetic patients exceeded that in the normal subjects (180±25 cm²/1.73 m², p<0.001). In the diabetic patients, the renal area index correlated with creatinine clearance (r=+0.43, p<0.05), but did not correlate with urinary albumin excretion, or the electron microscopic measurements of percentage total mesangium and glomerular basement membrane width. In diabetic patients with clinical nephropathy or severe glomerulopathy on biopsy, the kidneys may remain large. Thus, renal size does not indicate the severity of diabetic renal lesions on biopsy.

Original language	English (US)
Pages (from-to)	12-15
Number of pages	4
Journal	Diabetologia
Volume	28
Issue number	1
DOIs	https://doi.org/10.1007/BF00276993
State	Published - Jan 1985

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Kidney size
Type 1 diabetes
creatinine clearance
diabetic nephropathy
glomerular basement membrane
hypertension
mesangium
urinary albumin excretion

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10.1007/BF00276993

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title = "Relationship of renal size to nephropathy in Type 1 (insulin-dependent) diabetes",

abstract = "Thirty-five patients with Type 1 (insulin-dependent) diabetes mellitus and 90 normal subjects had renal size (renal area index) determined by X-ray and also had examination of renal biopsies by light and electron microscopy. Renal area index of 206±32 cm2/1.73 m2 (mean±SD) in the Type 1 diabetic patients exceeded that in the normal subjects (180±25 cm2/1.73 m2, p<0.001). In the diabetic patients, the renal area index correlated with creatinine clearance (r=+0.43, p<0.05), but did not correlate with urinary albumin excretion, or the electron microscopic measurements of percentage total mesangium and glomerular basement membrane width. In diabetic patients with clinical nephropathy or severe glomerulopathy on biopsy, the kidneys may remain large. Thus, renal size does not indicate the severity of diabetic renal lesions on biopsy.",

keywords = "Kidney size, Type 1 diabetes, creatinine clearance, diabetic nephropathy, glomerular basement membrane, hypertension, mesangium, urinary albumin excretion",

author = "Ellis, \{E. N.\} and Steffes, \{Michael W\} and Goetz, \{F. C.\} and Sutherland, \{D. E.R.\} and Michael Mauer",

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AU - Ellis, E. N.

AU - Steffes, Michael W

AU - Goetz, F. C.

AU - Sutherland, D. E.R.

AU - Mauer, Michael

PY - 1985/1

Y1 - 1985/1

N2 - Thirty-five patients with Type 1 (insulin-dependent) diabetes mellitus and 90 normal subjects had renal size (renal area index) determined by X-ray and also had examination of renal biopsies by light and electron microscopy. Renal area index of 206±32 cm2/1.73 m2 (mean±SD) in the Type 1 diabetic patients exceeded that in the normal subjects (180±25 cm2/1.73 m2, p<0.001). In the diabetic patients, the renal area index correlated with creatinine clearance (r=+0.43, p<0.05), but did not correlate with urinary albumin excretion, or the electron microscopic measurements of percentage total mesangium and glomerular basement membrane width. In diabetic patients with clinical nephropathy or severe glomerulopathy on biopsy, the kidneys may remain large. Thus, renal size does not indicate the severity of diabetic renal lesions on biopsy.

AB - Thirty-five patients with Type 1 (insulin-dependent) diabetes mellitus and 90 normal subjects had renal size (renal area index) determined by X-ray and also had examination of renal biopsies by light and electron microscopy. Renal area index of 206±32 cm2/1.73 m2 (mean±SD) in the Type 1 diabetic patients exceeded that in the normal subjects (180±25 cm2/1.73 m2, p<0.001). In the diabetic patients, the renal area index correlated with creatinine clearance (r=+0.43, p<0.05), but did not correlate with urinary albumin excretion, or the electron microscopic measurements of percentage total mesangium and glomerular basement membrane width. In diabetic patients with clinical nephropathy or severe glomerulopathy on biopsy, the kidneys may remain large. Thus, renal size does not indicate the severity of diabetic renal lesions on biopsy.

KW - Kidney size

KW - Type 1 diabetes

KW - creatinine clearance

KW - diabetic nephropathy

KW - glomerular basement membrane

KW - hypertension

KW - mesangium

KW - urinary albumin excretion

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ER -

Relationship of renal size to nephropathy in Type 1 (insulin-dependent) diabetes

Abstract

UN SDGs

Keywords

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