Relationship of renal size to nephropathy in Type 1 (insulin-dependent) diabetes

E. N. Ellis, Michael W Steffes, F. C. Goetz, D. E.R. Sutherland, Michael Mauer

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23 Scopus citations

Abstract

Thirty-five patients with Type 1 (insulin-dependent) diabetes mellitus and 90 normal subjects had renal size (renal area index) determined by X-ray and also had examination of renal biopsies by light and electron microscopy. Renal area index of 206±32 cm2/1.73 m2 (mean±SD) in the Type 1 diabetic patients exceeded that in the normal subjects (180±25 cm2/1.73 m2, p<0.001). In the diabetic patients, the renal area index correlated with creatinine clearance (r=+0.43, p<0.05), but did not correlate with urinary albumin excretion, or the electron microscopic measurements of percentage total mesangium and glomerular basement membrane width. In diabetic patients with clinical nephropathy or severe glomerulopathy on biopsy, the kidneys may remain large. Thus, renal size does not indicate the severity of diabetic renal lesions on biopsy.

Original languageEnglish (US)
Pages (from-to)12-15
Number of pages4
JournalDiabetologia
Volume28
Issue number1
DOIs
StatePublished - Jan 1985

Keywords

  • Kidney size
  • Type 1 diabetes
  • creatinine clearance
  • diabetic nephropathy
  • glomerular basement membrane
  • hypertension
  • mesangium
  • urinary albumin excretion

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