Relationship of Maternal Weight Status Before, During, and After Pregnancy with Breast Milk Hormone Concentrations

Ghazaleh Sadr Dadres, Kara M. Whitaker, Jacob L. Haapala, Laurie Foster, Katy D. Smith, April M. Teague, David R Jacobs Jr, Elyse O. Kharbanda, Patricia M McGovern, Tonya C Schoenfuss, Laura J. Le, Lisa J Harnack, David A. Fields, Ellen W Demerath

Research output: Contribution to journalArticle

Abstract

Objective: The aim of this study was to test associations of prepregnancy BMI, gestational weight gain, oral glucose challenge test results, and postpartum weight loss as predictors of breast milk leptin, insulin, and adiponectin concentrations and whether these relationships vary over time. Methods: Milk was collected at 1 and 3 months from 135 exclusively breastfeeding women from the longitudinal Mothers and Infants Linked for Healthy Growth (MILk) study. Hormones were assayed in skimmed samples using ELISA. Mixed-effects linear regression models were employed to assess main effects and effect-by-time interactions on hormone concentrations. Results: In adjusted models, BMI was positively associated with milk leptin (P < 0.001) and insulin (P = 0.03) and negatively associated with milk adiponectin (P = 0.02); however, the association was stronger with insulin and weaker with adiponectin at 3 months than at 1 month (time interaction P = 0.017 for insulin and P = 0.045 for adiponectin). Gestational weight gain was positively associated and postpartum weight loss was negatively associated with milk leptin (both P < 0.001), independent of BMI. Oral glucose challenge test results were not associated with these milk hormone concentrations. Conclusions: Maternal weight status before, during, and after pregnancy contributes to interindividual variation in human milk composition. Continuing work will assess the role of these and other milk bioactive factors in altering infant metabolic outcomes.

Original languageEnglish (US)
Pages (from-to)621-628
Number of pages8
JournalObesity
Volume27
Issue number4
DOIs
StatePublished - Apr 1 2019

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Human Milk
Milk
Adiponectin
Mothers
Hormones
Weights and Measures
Pregnancy
Leptin
Insulin
Postpartum Period
Weight Gain
Weight Loss
Linear Models
Glucose
Breast Feeding
Enzyme-Linked Immunosorbent Assay
Growth

PubMed: MeSH publication types

  • Journal Article

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Sadr Dadres, G., Whitaker, K. M., Haapala, J. L., Foster, L., Smith, K. D., Teague, A. M., ... Demerath, E. W. (2019). Relationship of Maternal Weight Status Before, During, and After Pregnancy with Breast Milk Hormone Concentrations. Obesity, 27(4), 621-628. https://doi.org/10.1002/oby.22409

Relationship of Maternal Weight Status Before, During, and After Pregnancy with Breast Milk Hormone Concentrations. / Sadr Dadres, Ghazaleh; Whitaker, Kara M.; Haapala, Jacob L.; Foster, Laurie; Smith, Katy D.; Teague, April M.; Jacobs Jr, David R; Kharbanda, Elyse O.; McGovern, Patricia M; Schoenfuss, Tonya C; Le, Laura J.; Harnack, Lisa J; Fields, David A.; Demerath, Ellen W.

In: Obesity, Vol. 27, No. 4, 01.04.2019, p. 621-628.

Research output: Contribution to journalArticle

Sadr Dadres, G, Whitaker, KM, Haapala, JL, Foster, L, Smith, KD, Teague, AM, Jacobs Jr, DR, Kharbanda, EO, McGovern, PM, Schoenfuss, TC, Le, LJ, Harnack, LJ, Fields, DA & Demerath, EW 2019, 'Relationship of Maternal Weight Status Before, During, and After Pregnancy with Breast Milk Hormone Concentrations', Obesity, vol. 27, no. 4, pp. 621-628. https://doi.org/10.1002/oby.22409
Sadr Dadres G, Whitaker KM, Haapala JL, Foster L, Smith KD, Teague AM et al. Relationship of Maternal Weight Status Before, During, and After Pregnancy with Breast Milk Hormone Concentrations. Obesity. 2019 Apr 1;27(4):621-628. https://doi.org/10.1002/oby.22409
Sadr Dadres, Ghazaleh ; Whitaker, Kara M. ; Haapala, Jacob L. ; Foster, Laurie ; Smith, Katy D. ; Teague, April M. ; Jacobs Jr, David R ; Kharbanda, Elyse O. ; McGovern, Patricia M ; Schoenfuss, Tonya C ; Le, Laura J. ; Harnack, Lisa J ; Fields, David A. ; Demerath, Ellen W. / Relationship of Maternal Weight Status Before, During, and After Pregnancy with Breast Milk Hormone Concentrations. In: Obesity. 2019 ; Vol. 27, No. 4. pp. 621-628.
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AU - Sadr Dadres, Ghazaleh

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AU - Haapala, Jacob L.

AU - Foster, Laurie

AU - Smith, Katy D.

AU - Teague, April M.

AU - Jacobs Jr, David R

AU - Kharbanda, Elyse O.

AU - McGovern, Patricia M

AU - Schoenfuss, Tonya C

AU - Le, Laura J.

AU - Harnack, Lisa J

AU - Fields, David A.

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AB - Objective: The aim of this study was to test associations of prepregnancy BMI, gestational weight gain, oral glucose challenge test results, and postpartum weight loss as predictors of breast milk leptin, insulin, and adiponectin concentrations and whether these relationships vary over time. Methods: Milk was collected at 1 and 3 months from 135 exclusively breastfeeding women from the longitudinal Mothers and Infants Linked for Healthy Growth (MILk) study. Hormones were assayed in skimmed samples using ELISA. Mixed-effects linear regression models were employed to assess main effects and effect-by-time interactions on hormone concentrations. Results: In adjusted models, BMI was positively associated with milk leptin (P < 0.001) and insulin (P = 0.03) and negatively associated with milk adiponectin (P = 0.02); however, the association was stronger with insulin and weaker with adiponectin at 3 months than at 1 month (time interaction P = 0.017 for insulin and P = 0.045 for adiponectin). Gestational weight gain was positively associated and postpartum weight loss was negatively associated with milk leptin (both P < 0.001), independent of BMI. Oral glucose challenge test results were not associated with these milk hormone concentrations. Conclusions: Maternal weight status before, during, and after pregnancy contributes to interindividual variation in human milk composition. Continuing work will assess the role of these and other milk bioactive factors in altering infant metabolic outcomes.

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