Relationship of Mast Cell Population and Endogenous Histamine Concentration in the Canine Stomach

J Ernesto Molina, Wallace P. Ritchie, David Grigg, Owen H. Wangensteen

Research output: Contribution to journalArticlepeer-review


The distribution of histamine and mast cells in the fundic, corporal and antral mucosa of the canine stomach was assayed. Twelve areas from each of 4 stomachs were studied. Mast cell profiles of these areas showed the cell population to be similar in all mucosal areas, although the greatest number of cells occurred deeper in the glandular mucosa of the antrum than in the glandular mucosa of the fundus and corpus. In contrast, the amount of histamine in the antral mucosa (73.3 ± 4.9 μg/g) was roughly one half of that noted in fundic and corporal mucosa (133.6 ± 1.4 μg/g), a difference which is statistically significant, (p<.05). One possible explanation for these observations is that the major portion of corporal and fundic histamine is not associated with mast cells.

Original languageEnglish (US)
Pages (from-to)71-73
Number of pages3
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number1
StatePublished - May 1967

Bibliographical note

Funding Information:
Supported by a US'PHS Grant, John A. Hartford Foundation and Donald J. Cowling Fund for Surgical Research.

Copyright 2016 Elsevier B.V., All rights reserved.


Dive into the research topics of 'Relationship of Mast Cell Population and Endogenous Histamine Concentration in the Canine Stomach'. Together they form a unique fingerprint.

Cite this