To examine clinical and psychophysiological correlates of lateral ventricular size, computerized tomographic (CT) scans were obtained on a sample of 88 patients who had experienced their first psychotic episode. Patients met DSM-III criteria for schizophrenia, schizophreniform disorder, or affective disorder with psychotic features. For patients with schizophrenia, large lateral ventricles were associated with unfavorable outcome. No association between outcome and ventricular size was found in patients with affective or schizophreniform disorder. Patients with mood disorders who had large ventricles consumed significantly greater amounts of alcohol than those with small ventricles. No differences were found between patients with large or small ventricles in premorbid functioning, smooth pursuit eye tracking, or electrodermal activity.
Bibliographical noteFunding Information:
Acknowledgment. This research was supported by grants from the National Institute of Mental Health (MH-44643) the Medical Research Council of Canada, the University of Minnesota Graduate School, the Canada Health and Welfare National Research Directorate Program, and the British Columbia Health Care Research Foundation. Joanna Katsanis was supported by a fellowship from the Medical Research Council of Canada while working on this project. The authors thank Margaret Moreau, Jonathan Fleming, and Tsung-Yi Lin for their help with this project.
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- Lateral ventricular size
- alcohol consumption
- electrodermal activity
- psychotic disorder
- smooth pursuit eye tracking