Relationship between serum concentrations of persistent organic pollutants and the prevalence of metabolic syndrome among non-diabetic adults

Results from the National Health and Nutrition Examination Survey 1999-2002

D. H. Lee, I. K. Lee, M. Porta, Michael W Steffes, David R Jacobs Jr

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246 Citations (Scopus)

Abstract

Aims/hypothesis: We recently reported associations of some persistent organic pollutants (POPs) with both prevalence of type 2 diabetes and insulin resistance in a US population with background exposure to POPs. Restricted to non-diabetic participants, we now investigate the relationship between POPs and the metabolic syndrome, a prediabetic state. Materials and methods: Cross-sectional associations were investigated in 721 non-diabetic participants aged ≥20 years. Nineteen POPs in five subclasses were selected because they were detectable in ≥60% of participants. Results: Among five POPs subclasses, organochlorine (OC) pesticides were most strongly and consistently associated with metabolic syndrome: adjusted odds ratios (ORs) of 1.0, 1.5, 2.3 and 5.3 across OC pesticide quartiles (p for trend <0.01). Dioxin-like polychlorinated biphenyls (PCBs) were also positively associated with adjusted ORs of 1.0, 1.1, 2.2 and 2.1 (p for trend = 0.01). However, non-dioxin-like PCBs showed an inverted U-shaped association with adjusted ORs of 1.0, 1.3, 1.8 and 1.0 (p for quadratic term <0.01). Associations of specific POPs varied across five components of the metabolic syndrome. OC pesticides were positively and significantly associated with four of the five components, especially elevated triacylglycerol and high fasting glucose, but not high blood pressure. PCBs were significantly associated with waist circumference, triacylglycerol and impaired fasting glucose. Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans showed small but significant associations only with high blood pressure. Conclusions/interpretation: This study suggests that the prevalence of a cluster of cardiovascular risk factors relates to background exposure to a mixture of POPs, several of which are also related to the prevalence of diabetes. POPs associated differentially with different components of the metabolic syndrome.

Original languageEnglish (US)
Pages (from-to)1841-1851
Number of pages11
JournalDiabetologia
Volume50
Issue number9
DOIs
StatePublished - Sep 1 2007

Fingerprint

Nutrition Surveys
Polychlorinated Biphenyls
Pesticides
Odds Ratio
Serum
Fasting
Triglycerides
Hypertension
Prediabetic State
Glucose
Dioxins
Waist Circumference
Type 2 Diabetes Mellitus
Insulin Resistance
Cross-Sectional Studies
Population

Keywords

  • Diabetes
  • Insulin resistance
  • Metabolic syndrome
  • Organochlorine pesticides
  • Persistent organic pollutants
  • Polychlorinated biphenyls

Cite this

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title = "Relationship between serum concentrations of persistent organic pollutants and the prevalence of metabolic syndrome among non-diabetic adults: Results from the National Health and Nutrition Examination Survey 1999-2002",
abstract = "Aims/hypothesis: We recently reported associations of some persistent organic pollutants (POPs) with both prevalence of type 2 diabetes and insulin resistance in a US population with background exposure to POPs. Restricted to non-diabetic participants, we now investigate the relationship between POPs and the metabolic syndrome, a prediabetic state. Materials and methods: Cross-sectional associations were investigated in 721 non-diabetic participants aged ≥20 years. Nineteen POPs in five subclasses were selected because they were detectable in ≥60{\%} of participants. Results: Among five POPs subclasses, organochlorine (OC) pesticides were most strongly and consistently associated with metabolic syndrome: adjusted odds ratios (ORs) of 1.0, 1.5, 2.3 and 5.3 across OC pesticide quartiles (p for trend <0.01). Dioxin-like polychlorinated biphenyls (PCBs) were also positively associated with adjusted ORs of 1.0, 1.1, 2.2 and 2.1 (p for trend = 0.01). However, non-dioxin-like PCBs showed an inverted U-shaped association with adjusted ORs of 1.0, 1.3, 1.8 and 1.0 (p for quadratic term <0.01). Associations of specific POPs varied across five components of the metabolic syndrome. OC pesticides were positively and significantly associated with four of the five components, especially elevated triacylglycerol and high fasting glucose, but not high blood pressure. PCBs were significantly associated with waist circumference, triacylglycerol and impaired fasting glucose. Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans showed small but significant associations only with high blood pressure. Conclusions/interpretation: This study suggests that the prevalence of a cluster of cardiovascular risk factors relates to background exposure to a mixture of POPs, several of which are also related to the prevalence of diabetes. POPs associated differentially with different components of the metabolic syndrome.",
keywords = "Diabetes, Insulin resistance, Metabolic syndrome, Organochlorine pesticides, Persistent organic pollutants, Polychlorinated biphenyls",
author = "Lee, {D. H.} and Lee, {I. K.} and M. Porta and Steffes, {Michael W} and {Jacobs Jr}, {David R}",
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T2 - Results from the National Health and Nutrition Examination Survey 1999-2002

AU - Lee, D. H.

AU - Lee, I. K.

AU - Porta, M.

AU - Steffes, Michael W

AU - Jacobs Jr, David R

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AB - Aims/hypothesis: We recently reported associations of some persistent organic pollutants (POPs) with both prevalence of type 2 diabetes and insulin resistance in a US population with background exposure to POPs. Restricted to non-diabetic participants, we now investigate the relationship between POPs and the metabolic syndrome, a prediabetic state. Materials and methods: Cross-sectional associations were investigated in 721 non-diabetic participants aged ≥20 years. Nineteen POPs in five subclasses were selected because they were detectable in ≥60% of participants. Results: Among five POPs subclasses, organochlorine (OC) pesticides were most strongly and consistently associated with metabolic syndrome: adjusted odds ratios (ORs) of 1.0, 1.5, 2.3 and 5.3 across OC pesticide quartiles (p for trend <0.01). Dioxin-like polychlorinated biphenyls (PCBs) were also positively associated with adjusted ORs of 1.0, 1.1, 2.2 and 2.1 (p for trend = 0.01). However, non-dioxin-like PCBs showed an inverted U-shaped association with adjusted ORs of 1.0, 1.3, 1.8 and 1.0 (p for quadratic term <0.01). Associations of specific POPs varied across five components of the metabolic syndrome. OC pesticides were positively and significantly associated with four of the five components, especially elevated triacylglycerol and high fasting glucose, but not high blood pressure. PCBs were significantly associated with waist circumference, triacylglycerol and impaired fasting glucose. Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans showed small but significant associations only with high blood pressure. Conclusions/interpretation: This study suggests that the prevalence of a cluster of cardiovascular risk factors relates to background exposure to a mixture of POPs, several of which are also related to the prevalence of diabetes. POPs associated differentially with different components of the metabolic syndrome.

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KW - Organochlorine pesticides

KW - Persistent organic pollutants

KW - Polychlorinated biphenyls

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