Relationship between carotid artery stiffness index, BNP and high-sensitivity CRP

Gautam R Shroff, Y. Y. Cen, D. A. Duprez, Bradley A Bart

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Arterial stiffness is an independent predictor of cardiovascular morbidity and mortality. Brain natriuretic peptide (BNP) and high-sensitivity C-reactive protein (hs-CRP) are considered as novel biomarkers that are useful in the prediction of early cardiovascular risk. We studied the relationship between carotid artery stiffness index β and the cardiovascular biomarkers BNP and hs-CRP in 55 consecutive subjects. Carotid artery stiffness was assessed using the stiffness index β derived from brachial artery blood pressure measurement and carotid ultrasonography. Venous blood samples were obtained for BNP and hs-CRP. Pearson's correlation coefficient suggested a strong bivariate relationship between carotid stiffness index β and age (r = 0.56, P < 0.0001), BNP (r = 0.45, P < 0.004) and hs-CRP (r = 0.26, P = 0.06), respectively. On multiple regression analysis, significant correlations were found between carotid stiffness index β and age (P = 0.004), BNP (P = 0.027) and hs-CRP (P = 0.029). These findings suggest that there is a relationship between intra-cardiac pressures (measured by BNP), vascular inflammation (measured by hs-CRP) and vascular stiffness. Cardiovascular biomarkers are thus associated with functional parameters of the vascular tree.

Original languageEnglish (US)
Pages (from-to)783-787
Number of pages5
JournalJournal of Human Hypertension
Issue number12
StatePublished - 2009


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