Relationship between Aging and Hematopoietic Cell Transplantation

Margaret C. Cupit-Link, Mukta Arora, William A. Wood, Shahrukh K. Hashmi

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Hematopoietic cell transplantation (HCT) is increasingly utilized as a treatment for malignancies in the elderly population. At the same time, research has elucidated the impacts of HCT on bone marrow progenitor cells, one of which is accelerated aging. Clonal hematopoiesis has also been observed to occur in the aging population, both with and without HCT. The interplay between natural aging, clonal hemoatpoiesis, and the effects of HCT on the bone marrow, has not yet been addressed. Herein we explore this relationship, and its important clinical implications.

Original languageEnglish (US)
Pages (from-to)1965-1970
Number of pages6
JournalBiology of Blood and Marrow Transplantation
Volume24
Issue number10
DOIs
StatePublished - Oct 2018

Bibliographical note

Publisher Copyright:
© 2018

Keywords

  • Aging
  • Clonal hematopoiesis
  • Hematopoietic cell transplantation

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