Relations between hemostasis variables and cardiovascular risk factors in middle-aged adults

Aaron R. Folsom, Maureen G. Conlan, C. E. Davis, Kenneth K. Wu

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


The relations between hemostatic variables and cardiovascular risk factors were examined in a biracial population sample of middle-aged adults. Fibrinogen, factor VII, factor VIII, von Willebrand factor, protein C, and antithrombin III levels varied considerably by age, sex, and race. Hemostatic variables also were associated with several life-style and biochemical risk factors. For the most part, higher levels of the risk factors were associated with higher levels of the hemostatic variables. The findings point to potential confounders that warrant consideration in cardiovascular disease studies, and/or mechanisms by which cardiovascular risk is conferred. They also suggest that modification of the cardiovascular risk factors may have the potential to alter the risk of thrombosis.

Original languageEnglish (US)
Pages (from-to)481-494
Number of pages14
JournalAnnals of epidemiology
Issue number4
StatePublished - Jul 1992


  • ARIC Study
  • Antithrombin III
  • blood coagulation factors
  • coronary disease
  • factor VII
  • factor VIII
  • fibrinogen
  • protein C
  • von Willebrand factor


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