TY - JOUR
T1 - Relation of cardiometabolic risk factors between parents and children
AU - Halvorsen, Tanya
AU - Moran, Antoinette
AU - Jacobs, David R.
AU - Steffen, Lyn M.
AU - Sinaiko, Alan R.
AU - Zhou, Xia
AU - Steinberger, Julia
N1 - Publisher Copyright:
Copyright © 2015 Elsevier Inc. All rights reserved.
PY - 2015/11
Y1 - 2015/11
N2 - Objectives To explore the relations of parent-child cardiometabolic risk factors and assess the influence of adiposity on these associations. Study design Associations of adiposity, blood pressure (BP), lipids, fasting insulin and glucose, and a risk factor cluster score (CS) were evaluated in a cross-sectional study of 179 parents and their children (6-18 years, N = 255). Insulin resistance was assessed by euglycemic clamp in parents and children aged 10 years or older. Metabolic syndrome in parents was defined by National Cholesterol Education Program's Adult Treatment Panel III criteria. CSs of the risk factors were created based on age-specific z-scores. Analyses included Pearson correlation and linear regression, adjusted for parent and child age, sex, race, and body mass index (BMI), accounting for within-family correlation. Results We found positive parent-child correlations for measures of adiposity (BMI, BMI percentile, waist, subcutaneous fat, and visceral fat; r = 0.22-0.34, all P ≤.003), systolic BP (r = 0.20, P =.002), total cholesterol (r = 0.39, P <.001), low-density lipoprotein cholesterol (r = 0.34, P <.001), high density lipoprotein cholesterol (r = 0.26, P <.001), triglycerides (r = 0.19, P =.01), and insulin sensitivity (r = 0.22, P =.02) as well as CSs (r = 0.15, P =.02). After adjustment for BMI all parent-child correlations, except systolic BP, remained significant. Conclusions Although adiposity is strongly correlated between parents and children, many cardiometabolic risk factors correlate independent of parent and child BMI. Adverse parental cardiometabolic profiles may identify at-risk children independent of the child's adiposity status.
AB - Objectives To explore the relations of parent-child cardiometabolic risk factors and assess the influence of adiposity on these associations. Study design Associations of adiposity, blood pressure (BP), lipids, fasting insulin and glucose, and a risk factor cluster score (CS) were evaluated in a cross-sectional study of 179 parents and their children (6-18 years, N = 255). Insulin resistance was assessed by euglycemic clamp in parents and children aged 10 years or older. Metabolic syndrome in parents was defined by National Cholesterol Education Program's Adult Treatment Panel III criteria. CSs of the risk factors were created based on age-specific z-scores. Analyses included Pearson correlation and linear regression, adjusted for parent and child age, sex, race, and body mass index (BMI), accounting for within-family correlation. Results We found positive parent-child correlations for measures of adiposity (BMI, BMI percentile, waist, subcutaneous fat, and visceral fat; r = 0.22-0.34, all P ≤.003), systolic BP (r = 0.20, P =.002), total cholesterol (r = 0.39, P <.001), low-density lipoprotein cholesterol (r = 0.34, P <.001), high density lipoprotein cholesterol (r = 0.26, P <.001), triglycerides (r = 0.19, P =.01), and insulin sensitivity (r = 0.22, P =.02) as well as CSs (r = 0.15, P =.02). After adjustment for BMI all parent-child correlations, except systolic BP, remained significant. Conclusions Although adiposity is strongly correlated between parents and children, many cardiometabolic risk factors correlate independent of parent and child BMI. Adverse parental cardiometabolic profiles may identify at-risk children independent of the child's adiposity status.
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U2 - 10.1016/j.jpeds.2015.07.053
DO - 10.1016/j.jpeds.2015.07.053
M3 - Article
C2 - 26307644
AN - SCOPUS:84939627754
SN - 0022-3476
VL - 167
SP - 1049-1056.e2
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 5
ER -