Relation of Blood Pressure in Childhood to Self-Reported Hypertension in Adulthood

Elaine M. Urbina, Philip R. Khoury, Lydia Bazzano, Trudy L. Burns, Stephen Daniels, Terrence Dwyer, Tian Hu, David R Jacobs Jr, Markus Juonala, Ronald Prineas, Olli Raitakari, Julia Steinberger, Alison Venn, Jessica G. Woo, Alan R Sinaiko

Research output: Contribution to journalArticle

Abstract

Blood pressure (BP) tracking (maintaining a BP percentile) across life is not well defined but is important in predicting which children will become hypertensive adults. We computed BP tracking in subjects with BP measured in childhood and adulthood and performed logistic regression to determine the ability of childhood BP to predict adult hypertension (N=5035, 46.7 years, 74.2% white, 17.7% black; 39.6% male). Prevalence of hypertension was 29%. Correlations between systolic BP for child and adolescent were r=0.48; for adolescent and young adult were r=0.40, and for child and young adult were r=0.24 (all P<0.0001). Participants self-reporting adult hypertension were less likely to be white (38.7% black, 27.6% white, 20.9% other; P<0.0001) and female (26.4% females, 32.9% male, P<0.0001). Participants with adult hypertension were more likely to have higher BP and adiposity by age 10 years and abnormal lipids and glucose by age 16 years. There was a graded increase in the frequency of self-reported adult hypertension across the BP change groups, even within the persistently normotensive group (X2<0.0001) from 19% in children with a systolic BP% persistently below the median to 80% for individuals with elevated BP in both childhood and adolescence. Although our precision to predict which individual child is at risk of adult BP-related cardiovascular disease is weak, an increase in systolic BP and body mass index percentile from childhood to adolescence should signal a need for lifestyle intervention to prevent future sustained hypertension-related cardiovascular disease.

Original languageEnglish (US)
Pages (from-to)1224-1230
Number of pages7
JournalHypertension (Dallas, Tex. : 1979)
Volume73
Issue number6
DOIs
StatePublished - Jun 1 2019

Fingerprint

Blood Pressure
Hypertension
Young Adult
Cardiovascular Diseases
Aptitude
Adiposity
Life Style
Body Mass Index
Logistic Models
Lipids
Glucose

Keywords

  • adiposity
  • blood pressure
  • hypertension
  • obesity
  • risk factor

Cite this

Relation of Blood Pressure in Childhood to Self-Reported Hypertension in Adulthood. / Urbina, Elaine M.; Khoury, Philip R.; Bazzano, Lydia; Burns, Trudy L.; Daniels, Stephen; Dwyer, Terrence; Hu, Tian; Jacobs Jr, David R; Juonala, Markus; Prineas, Ronald; Raitakari, Olli; Steinberger, Julia; Venn, Alison; Woo, Jessica G.; Sinaiko, Alan R.

In: Hypertension (Dallas, Tex. : 1979), Vol. 73, No. 6, 01.06.2019, p. 1224-1230.

Research output: Contribution to journalArticle

Urbina, EM, Khoury, PR, Bazzano, L, Burns, TL, Daniels, S, Dwyer, T, Hu, T, Jacobs Jr, DR, Juonala, M, Prineas, R, Raitakari, O, Steinberger, J, Venn, A, Woo, JG & Sinaiko, AR 2019, 'Relation of Blood Pressure in Childhood to Self-Reported Hypertension in Adulthood', Hypertension (Dallas, Tex. : 1979), vol. 73, no. 6, pp. 1224-1230. https://doi.org/10.1161/HYPERTENSIONAHA.118.12334
Urbina, Elaine M. ; Khoury, Philip R. ; Bazzano, Lydia ; Burns, Trudy L. ; Daniels, Stephen ; Dwyer, Terrence ; Hu, Tian ; Jacobs Jr, David R ; Juonala, Markus ; Prineas, Ronald ; Raitakari, Olli ; Steinberger, Julia ; Venn, Alison ; Woo, Jessica G. ; Sinaiko, Alan R. / Relation of Blood Pressure in Childhood to Self-Reported Hypertension in Adulthood. In: Hypertension (Dallas, Tex. : 1979). 2019 ; Vol. 73, No. 6. pp. 1224-1230.
@article{0b6b81cdeff048bc909321b83ccff025,
title = "Relation of Blood Pressure in Childhood to Self-Reported Hypertension in Adulthood",
abstract = "Blood pressure (BP) tracking (maintaining a BP percentile) across life is not well defined but is important in predicting which children will become hypertensive adults. We computed BP tracking in subjects with BP measured in childhood and adulthood and performed logistic regression to determine the ability of childhood BP to predict adult hypertension (N=5035, 46.7 years, 74.2{\%} white, 17.7{\%} black; 39.6{\%} male). Prevalence of hypertension was 29{\%}. Correlations between systolic BP for child and adolescent were r=0.48; for adolescent and young adult were r=0.40, and for child and young adult were r=0.24 (all P<0.0001). Participants self-reporting adult hypertension were less likely to be white (38.7{\%} black, 27.6{\%} white, 20.9{\%} other; P<0.0001) and female (26.4{\%} females, 32.9{\%} male, P<0.0001). Participants with adult hypertension were more likely to have higher BP and adiposity by age 10 years and abnormal lipids and glucose by age 16 years. There was a graded increase in the frequency of self-reported adult hypertension across the BP change groups, even within the persistently normotensive group (X2<0.0001) from 19{\%} in children with a systolic BP{\%} persistently below the median to 80{\%} for individuals with elevated BP in both childhood and adolescence. Although our precision to predict which individual child is at risk of adult BP-related cardiovascular disease is weak, an increase in systolic BP and body mass index percentile from childhood to adolescence should signal a need for lifestyle intervention to prevent future sustained hypertension-related cardiovascular disease.",
keywords = "adiposity, blood pressure, hypertension, obesity, risk factor",
author = "Urbina, {Elaine M.} and Khoury, {Philip R.} and Lydia Bazzano and Burns, {Trudy L.} and Stephen Daniels and Terrence Dwyer and Tian Hu and {Jacobs Jr}, {David R} and Markus Juonala and Ronald Prineas and Olli Raitakari and Julia Steinberger and Alison Venn and Woo, {Jessica G.} and Sinaiko, {Alan R}",
year = "2019",
month = "6",
day = "1",
doi = "10.1161/HYPERTENSIONAHA.118.12334",
language = "English (US)",
volume = "73",
pages = "1224--1230",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Relation of Blood Pressure in Childhood to Self-Reported Hypertension in Adulthood

AU - Urbina, Elaine M.

AU - Khoury, Philip R.

AU - Bazzano, Lydia

AU - Burns, Trudy L.

AU - Daniels, Stephen

AU - Dwyer, Terrence

AU - Hu, Tian

AU - Jacobs Jr, David R

AU - Juonala, Markus

AU - Prineas, Ronald

AU - Raitakari, Olli

AU - Steinberger, Julia

AU - Venn, Alison

AU - Woo, Jessica G.

AU - Sinaiko, Alan R

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Blood pressure (BP) tracking (maintaining a BP percentile) across life is not well defined but is important in predicting which children will become hypertensive adults. We computed BP tracking in subjects with BP measured in childhood and adulthood and performed logistic regression to determine the ability of childhood BP to predict adult hypertension (N=5035, 46.7 years, 74.2% white, 17.7% black; 39.6% male). Prevalence of hypertension was 29%. Correlations between systolic BP for child and adolescent were r=0.48; for adolescent and young adult were r=0.40, and for child and young adult were r=0.24 (all P<0.0001). Participants self-reporting adult hypertension were less likely to be white (38.7% black, 27.6% white, 20.9% other; P<0.0001) and female (26.4% females, 32.9% male, P<0.0001). Participants with adult hypertension were more likely to have higher BP and adiposity by age 10 years and abnormal lipids and glucose by age 16 years. There was a graded increase in the frequency of self-reported adult hypertension across the BP change groups, even within the persistently normotensive group (X2<0.0001) from 19% in children with a systolic BP% persistently below the median to 80% for individuals with elevated BP in both childhood and adolescence. Although our precision to predict which individual child is at risk of adult BP-related cardiovascular disease is weak, an increase in systolic BP and body mass index percentile from childhood to adolescence should signal a need for lifestyle intervention to prevent future sustained hypertension-related cardiovascular disease.

AB - Blood pressure (BP) tracking (maintaining a BP percentile) across life is not well defined but is important in predicting which children will become hypertensive adults. We computed BP tracking in subjects with BP measured in childhood and adulthood and performed logistic regression to determine the ability of childhood BP to predict adult hypertension (N=5035, 46.7 years, 74.2% white, 17.7% black; 39.6% male). Prevalence of hypertension was 29%. Correlations between systolic BP for child and adolescent were r=0.48; for adolescent and young adult were r=0.40, and for child and young adult were r=0.24 (all P<0.0001). Participants self-reporting adult hypertension were less likely to be white (38.7% black, 27.6% white, 20.9% other; P<0.0001) and female (26.4% females, 32.9% male, P<0.0001). Participants with adult hypertension were more likely to have higher BP and adiposity by age 10 years and abnormal lipids and glucose by age 16 years. There was a graded increase in the frequency of self-reported adult hypertension across the BP change groups, even within the persistently normotensive group (X2<0.0001) from 19% in children with a systolic BP% persistently below the median to 80% for individuals with elevated BP in both childhood and adolescence. Although our precision to predict which individual child is at risk of adult BP-related cardiovascular disease is weak, an increase in systolic BP and body mass index percentile from childhood to adolescence should signal a need for lifestyle intervention to prevent future sustained hypertension-related cardiovascular disease.

KW - adiposity

KW - blood pressure

KW - hypertension

KW - obesity

KW - risk factor

UR - http://www.scopus.com/inward/record.url?scp=85065772600&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065772600&partnerID=8YFLogxK

U2 - 10.1161/HYPERTENSIONAHA.118.12334

DO - 10.1161/HYPERTENSIONAHA.118.12334

M3 - Article

VL - 73

SP - 1224

EP - 1230

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 6

ER -