Reinforcement by orally delivered methadone, cocaine, and methadone-cocaine combinations in rhesus monkeys: Are the combinations better reinforcers?

N. S. Wang, V. L. Brown, J. Grabowski, R. A. Meisch

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Rationale: Polydrug abuse is a problem that has been infrequently examined. In the present study, drug self-administration procedures were used to investigate the reinforcing effects of drug combinations. Objectives: To determine the absolute and relative response rates maintained by orally delivered methadone, cocaine, and their combinations under sequential and concurrent access. Choice between drug combinations containing different concentrations of cocaine was also determined. Methods: Oral intake of methadone, cocaine, and their combinations was studied with rhesus monkeys during daily 3-h sessions. Lip contact (the operant response) was reinforced by delivery of liquid contingent upon completion of a fixed-ratio schedule. In one series, the drugs and drug combinations were studied sequentially with the water vehicle concurrently available. In the next series, the drugs and drug combinations were concurrently available. In the third series, pairs of drug combinations containing different concentrations of cocaine were also concurrently available. Results: Methadone, cocaine and their combinations functioned as reinforcers. Under sequential access, response rates for the drug combinations and the component drugs were often similar. However, under concurrent access, response rates for the drug combinations were greater than response rates for the component drugs at the highest FR size for each condition. Also, drug combinations containing higher cocaine concentrations were preferred to combinations containing lower cocaine concentrations. Conclusions: Combinations of methadone and cocaine have relatively greater reinforcing effects than the component drugs, and these greater reinforcing effects are better detected with concurrent measures than with sequential measures.

Original languageEnglish (US)
Pages (from-to)63-72
Number of pages10
JournalPsychopharmacology
Volume156
Issue number1
DOIs
StatePublished - Jul 25 2001

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Methadone
Drug Combinations
Macaca mulatta
Cocaine
Pharmaceutical Preparations
Self Administration
Lip
Appointments and Schedules
Water

Keywords

  • Cocaine
  • Drug combination
  • Drug reinforcement
  • Drug self-administration
  • Methadone
  • Oral route
  • Polydrug abuse
  • Rhesus monkey

Cite this

Reinforcement by orally delivered methadone, cocaine, and methadone-cocaine combinations in rhesus monkeys : Are the combinations better reinforcers? / Wang, N. S.; Brown, V. L.; Grabowski, J.; Meisch, R. A.

In: Psychopharmacology, Vol. 156, No. 1, 25.07.2001, p. 63-72.

Research output: Contribution to journalArticle

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N2 - Rationale: Polydrug abuse is a problem that has been infrequently examined. In the present study, drug self-administration procedures were used to investigate the reinforcing effects of drug combinations. Objectives: To determine the absolute and relative response rates maintained by orally delivered methadone, cocaine, and their combinations under sequential and concurrent access. Choice between drug combinations containing different concentrations of cocaine was also determined. Methods: Oral intake of methadone, cocaine, and their combinations was studied with rhesus monkeys during daily 3-h sessions. Lip contact (the operant response) was reinforced by delivery of liquid contingent upon completion of a fixed-ratio schedule. In one series, the drugs and drug combinations were studied sequentially with the water vehicle concurrently available. In the next series, the drugs and drug combinations were concurrently available. In the third series, pairs of drug combinations containing different concentrations of cocaine were also concurrently available. Results: Methadone, cocaine and their combinations functioned as reinforcers. Under sequential access, response rates for the drug combinations and the component drugs were often similar. However, under concurrent access, response rates for the drug combinations were greater than response rates for the component drugs at the highest FR size for each condition. Also, drug combinations containing higher cocaine concentrations were preferred to combinations containing lower cocaine concentrations. Conclusions: Combinations of methadone and cocaine have relatively greater reinforcing effects than the component drugs, and these greater reinforcing effects are better detected with concurrent measures than with sequential measures.

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