Regulatory roles of vertebrate Nocturnin: insights and remaining mysteries

Kelsey L. Hughes, Elizabeth T. Abshire, Aaron Goldstrohm

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Post-transcriptional control of messenger RNA (mRNA) is an important layer of gene regulation that modulates mRNA decay, translation, and localization. Eukaryotic mRNA decay begins with the catalytic removal of the 3′ poly-adenosine tail by deadenylase enzymes. Multiple deadenylases have been identified in vertebrates and are known to have distinct biological roles; among these proteins is Nocturnin, which has been linked to circadian biology, adipogenesis, osteogenesis, and obesity. Multiple studies have investigated Nocturnin’s involvement in these processes; however, a full understanding of its molecular function remains elusive. Recent studies have provided new insights by identifying putative Nocturnin-regulated mRNAs in mice and by determining the structure and regulatory activities of human Nocturnin. This review seeks to integrate these new discoveries into our understanding of Nocturnin’s regulatory functions and highlight the important remaining unanswered questions surrounding its regulation, biochemical activities, protein partners, and target mRNAs.

Original languageEnglish (US)
Pages (from-to)1255-1267
Number of pages13
JournalRNA Biology
Volume15
Issue number10
DOIs
StatePublished - Oct 3 2018

Fingerprint

Vertebrates
Messenger RNA
RNA Stability
Adipogenesis
Osteogenesis
Human Activities
Adenosine
Tail
Proteins
Obesity
nocturnin
Enzymes
Genes

Keywords

  • NOCT
  • Nocturnin
  • RNA decay
  • deadenylase
  • translational control

Cite this

Regulatory roles of vertebrate Nocturnin : insights and remaining mysteries. / Hughes, Kelsey L.; Abshire, Elizabeth T.; Goldstrohm, Aaron.

In: RNA Biology, Vol. 15, No. 10, 03.10.2018, p. 1255-1267.

Research output: Contribution to journalReview article

Hughes, Kelsey L. ; Abshire, Elizabeth T. ; Goldstrohm, Aaron. / Regulatory roles of vertebrate Nocturnin : insights and remaining mysteries. In: RNA Biology. 2018 ; Vol. 15, No. 10. pp. 1255-1267.
@article{1ae932f885b74e7fa0dec373ebe8d5e9,
title = "Regulatory roles of vertebrate Nocturnin: insights and remaining mysteries",
abstract = "Post-transcriptional control of messenger RNA (mRNA) is an important layer of gene regulation that modulates mRNA decay, translation, and localization. Eukaryotic mRNA decay begins with the catalytic removal of the 3′ poly-adenosine tail by deadenylase enzymes. Multiple deadenylases have been identified in vertebrates and are known to have distinct biological roles; among these proteins is Nocturnin, which has been linked to circadian biology, adipogenesis, osteogenesis, and obesity. Multiple studies have investigated Nocturnin’s involvement in these processes; however, a full understanding of its molecular function remains elusive. Recent studies have provided new insights by identifying putative Nocturnin-regulated mRNAs in mice and by determining the structure and regulatory activities of human Nocturnin. This review seeks to integrate these new discoveries into our understanding of Nocturnin’s regulatory functions and highlight the important remaining unanswered questions surrounding its regulation, biochemical activities, protein partners, and target mRNAs.",
keywords = "NOCT, Nocturnin, RNA decay, deadenylase, translational control",
author = "Hughes, {Kelsey L.} and Abshire, {Elizabeth T.} and Aaron Goldstrohm",
year = "2018",
month = "10",
day = "3",
doi = "10.1080/15476286.2018.1526541",
language = "English (US)",
volume = "15",
pages = "1255--1267",
journal = "RNA Biology",
issn = "1547-6286",
publisher = "Landes Bioscience",
number = "10",

}

TY - JOUR

T1 - Regulatory roles of vertebrate Nocturnin

T2 - insights and remaining mysteries

AU - Hughes, Kelsey L.

AU - Abshire, Elizabeth T.

AU - Goldstrohm, Aaron

PY - 2018/10/3

Y1 - 2018/10/3

N2 - Post-transcriptional control of messenger RNA (mRNA) is an important layer of gene regulation that modulates mRNA decay, translation, and localization. Eukaryotic mRNA decay begins with the catalytic removal of the 3′ poly-adenosine tail by deadenylase enzymes. Multiple deadenylases have been identified in vertebrates and are known to have distinct biological roles; among these proteins is Nocturnin, which has been linked to circadian biology, adipogenesis, osteogenesis, and obesity. Multiple studies have investigated Nocturnin’s involvement in these processes; however, a full understanding of its molecular function remains elusive. Recent studies have provided new insights by identifying putative Nocturnin-regulated mRNAs in mice and by determining the structure and regulatory activities of human Nocturnin. This review seeks to integrate these new discoveries into our understanding of Nocturnin’s regulatory functions and highlight the important remaining unanswered questions surrounding its regulation, biochemical activities, protein partners, and target mRNAs.

AB - Post-transcriptional control of messenger RNA (mRNA) is an important layer of gene regulation that modulates mRNA decay, translation, and localization. Eukaryotic mRNA decay begins with the catalytic removal of the 3′ poly-adenosine tail by deadenylase enzymes. Multiple deadenylases have been identified in vertebrates and are known to have distinct biological roles; among these proteins is Nocturnin, which has been linked to circadian biology, adipogenesis, osteogenesis, and obesity. Multiple studies have investigated Nocturnin’s involvement in these processes; however, a full understanding of its molecular function remains elusive. Recent studies have provided new insights by identifying putative Nocturnin-regulated mRNAs in mice and by determining the structure and regulatory activities of human Nocturnin. This review seeks to integrate these new discoveries into our understanding of Nocturnin’s regulatory functions and highlight the important remaining unanswered questions surrounding its regulation, biochemical activities, protein partners, and target mRNAs.

KW - NOCT

KW - Nocturnin

KW - RNA decay

KW - deadenylase

KW - translational control

UR - http://www.scopus.com/inward/record.url?scp=85056519497&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056519497&partnerID=8YFLogxK

U2 - 10.1080/15476286.2018.1526541

DO - 10.1080/15476286.2018.1526541

M3 - Review article

C2 - 30257600

AN - SCOPUS:85056519497

VL - 15

SP - 1255

EP - 1267

JO - RNA Biology

JF - RNA Biology

SN - 1547-6286

IS - 10

ER -