Regulatory mechanisms for glycogenolysis and K+ uptake in brain astrocytes

Mauro Dinuzzo, Silvia Mangia, Bruno Maraviglia, Federico Giove

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


Recent advances in brain energy metabolism support the notion that glycogen in astrocytes is necessary for the clearance of neuronally-released K + from the extracellular space. However, how the multiple metabolic pathways involved in K+-induced increase in glycogen turnover are regulated is only partly understood. Here we summarize the current knowledge about the mechanisms that control glycogen metabolism during enhanced K + uptake. We also describe the action of the ubiquitous Na +/K+ ATPase for both ion transport and intracellular signaling cascades, and emphasize its importance in understanding the complex relation between glycogenolysis and K+ uptake.

Original languageEnglish (US)
Pages (from-to)458-464
Number of pages7
JournalNeurochemistry International
Issue number5
StatePublished - 2013

Bibliographical note

Funding Information:
The author S.M. thanks the support from the NIH grant 1UL1RR033183 and KL2 RR033182 to the University of Minnesota Clinical and Translational Science Institute (CTSI).


  • ATPase
  • Astrocytes
  • Glycogen
  • Glycogen phosphorylase
  • Na/K
  • Potassium


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