Regulatory mechanisms for glycogenolysis and K+ uptake in brain astrocytes

Mauro Dinuzzo, Silvia Mangia, Bruno Maraviglia, Federico Giove

Research output: Contribution to journalReview article

21 Citations (Scopus)

Abstract

Recent advances in brain energy metabolism support the notion that glycogen in astrocytes is necessary for the clearance of neuronally-released K + from the extracellular space. However, how the multiple metabolic pathways involved in K+-induced increase in glycogen turnover are regulated is only partly understood. Here we summarize the current knowledge about the mechanisms that control glycogen metabolism during enhanced K + uptake. We also describe the action of the ubiquitous Na +/K+ ATPase for both ion transport and intracellular signaling cascades, and emphasize its importance in understanding the complex relation between glycogenolysis and K+ uptake.

Original languageEnglish (US)
Pages (from-to)458-464
Number of pages7
JournalNeurochemistry International
Volume63
Issue number5
DOIs
StatePublished - Sep 11 2013

Fingerprint

Glycogenolysis
Glycogen
Astrocytes
Brain
Ion Transport
Extracellular Space
Metabolic Networks and Pathways
Energy Metabolism

Keywords

  • ATPase
  • Astrocytes
  • Glycogen
  • Glycogen phosphorylase
  • Na/K
  • Potassium

Cite this

Regulatory mechanisms for glycogenolysis and K+ uptake in brain astrocytes. / Dinuzzo, Mauro; Mangia, Silvia; Maraviglia, Bruno; Giove, Federico.

In: Neurochemistry International, Vol. 63, No. 5, 11.09.2013, p. 458-464.

Research output: Contribution to journalReview article

Dinuzzo, Mauro ; Mangia, Silvia ; Maraviglia, Bruno ; Giove, Federico. / Regulatory mechanisms for glycogenolysis and K+ uptake in brain astrocytes. In: Neurochemistry International. 2013 ; Vol. 63, No. 5. pp. 458-464.
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