Regulators of immunological responses in the cornea and the anterior chamber of the eye

Martine J. Jager; Dale S. Gregerson; J. Wayne Streilein

doi:10.1038/eye.1995.47

Regulators of immunological responses in the cornea and the anterior chamber of the eye

Martine J. Jager, Dale S. Gregerson, J. Wayne Streilein

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Although the eye is considered to be immunologically privileged, this privilege is not absolute. This is well demonstrated by, for example, the fate of corneal transplantations. Clinical studies in man and experimental studies in animals have shown thasurvival of a corneal transplant depends on the local condition of the cornea and the anterior chamber of the eye. The presence of neovascularisation or Langerhans cells in the recipient cornea endangers the graft, while the intracorneal production of immunosuppressive factors may inhibit the development of rejection. The balance between suppressive and stimulatory factors determines whether a local immune response will develop.

Original language	English (US)
Pages (from-to)	241-246
Number of pages	6
Journal	Eye (Basingstoke)
Volume	9
Issue number	2
DOIs	https://doi.org/10.1038/eye.1995.47
State	Published - Mar 1995
Externally published	Yes

Bibliographical note

Funding Information:
Part of this work was performed at the Department of Microbiology and Immunology, University of Miami, and the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA. Dr Jager is the recipient of a fellowship from the Royal Netherlands Academy of the Arts and Sciences. Dr Gregerson's work was supported by NIH grant EY 09207. Dr Streilein's work was supported by NIH grant EY 05678.

Keywords

Cornea
Cytokines
Immunogenesis
Immunosuppression

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10.1038/eye.1995.47

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title = "Regulators of immunological responses in the cornea and the anterior chamber of the eye",

abstract = "Although the eye is considered to be immunologically privileged, this privilege is not absolute. This is well demonstrated by, for example, the fate of corneal transplantations. Clinical studies in man and experimental studies in animals have shown thasurvival of a corneal transplant depends on the local condition of the cornea and the anterior chamber of the eye. The presence of neovascularisation or Langerhans cells in the recipient cornea endangers the graft, while the intracorneal production of immunosuppressive factors may inhibit the development of rejection. The balance between suppressive and stimulatory factors determines whether a local immune response will develop.",

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note = "Funding Information: Part of this work was performed at the Department of Microbiology and Immunology, University of Miami, and the Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami, Miami, Florida, USA. Dr Jager is the recipient of a fellowship from the Royal Netherlands Academy of the Arts and Sciences. Dr Gregerson's work was supported by NIH grant EY 09207. Dr Streilein's work was supported by NIH grant EY 05678.",

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AU - Gregerson, Dale S.

AU - Streilein, J. Wayne

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AB - Although the eye is considered to be immunologically privileged, this privilege is not absolute. This is well demonstrated by, for example, the fate of corneal transplantations. Clinical studies in man and experimental studies in animals have shown thasurvival of a corneal transplant depends on the local condition of the cornea and the anterior chamber of the eye. The presence of neovascularisation or Langerhans cells in the recipient cornea endangers the graft, while the intracorneal production of immunosuppressive factors may inhibit the development of rejection. The balance between suppressive and stimulatory factors determines whether a local immune response will develop.

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Regulators of immunological responses in the cornea and the anterior chamber of the eye

Abstract

Bibliographical note

Keywords

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