Regulation of tyrosine biosynthesis by phenylalanine in anthramycin-producing streptomyces refuineus

Marilyn K. Speedie, Myung Ock Park

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The regulation of tyrosine production in the anthramycin-producing organism Streptomyces refuineus var. thermotolerans has been studied with wild-type and tyrosine auxotrophic organisms. Growth of the auxotroph on minimal medium plus phenylalanine suggested that phenylalanine may increase the supply of tyrosine. In incubation with whole cells, tyrosine levels increased in response to added phenylalanine. However, no radiolabeled tyrosine was detected after incubation with 14C-phenylalanine. Thus, no phenylalanine hydroxylase is present. Phenylalanine was found to feedback inhibit prephenate dehydratase, resulting in an increase in NAD-dependent prephenate dehydrogenase activity, thus channeling prephenic acid toward tyrosine.

Original languageEnglish (US)
Pages (from-to)579-584
Number of pages6
JournalThe Journal of Antibiotics
Volume33
Issue number6
DOIs
StatePublished - Jan 1 1980

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