Pretreatment of mouse spleen cells with polyadenylic-polyuridylic acid complexes (poly A:U) either in vivo or in vitro 24 hr prior to addition of antigen, resulted in a substantial time dependent decrease in anti-SRBC PFC. Enhancement was observed 6 hr after poly A:U, while inhibition did not become evident until 24 hr after pretreatment. Inhibition of the PFC response appeared to result from poly A:U activation of a nylon wool adherent, T suppressor cell, capable of diminishing the response of normal spleen cells exposed to antigen on co-culture.
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1 This work was supported by USPHS