Regulation of the immune system by synthetic polynucleotides. VII. Suppression induced by pretreatment with poly A: U

Clarice K. Morris; Arthur G. Johnson

doi:10.1016/0008-8749(78)90110-7

Regulation of the immune system by synthetic polynucleotides. VII. Suppression induced by pretreatment with poly A: U

Clarice K. Morris, Arthur G. Johnson

Biomedical Sciences

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17 Scopus citations

Abstract

Pretreatment of mouse spleen cells with polyadenylic-polyuridylic acid complexes (poly A:U) either in vivo or in vitro 24 hr prior to addition of antigen, resulted in a substantial time dependent decrease in anti-SRBC PFC. Enhancement was observed 6 hr after poly A:U, while inhibition did not become evident until 24 hr after pretreatment. Inhibition of the PFC response appeared to result from poly A:U activation of a nylon wool adherent, T suppressor cell, capable of diminishing the response of normal spleen cells exposed to antigen on co-culture.

Original language	English (US)
Pages (from-to)	345-354
Number of pages	10
Journal	Cellular Immunology
Volume	39
Issue number	2
DOIs	https://doi.org/10.1016/0008-8749(78)90110-7
State	Published - Sep 1 1978

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Funding Information:
1 This work was supported by USPHS

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abstract = "Pretreatment of mouse spleen cells with polyadenylic-polyuridylic acid complexes (poly A:U) either in vivo or in vitro 24 hr prior to addition of antigen, resulted in a substantial time dependent decrease in anti-SRBC PFC. Enhancement was observed 6 hr after poly A:U, while inhibition did not become evident until 24 hr after pretreatment. Inhibition of the PFC response appeared to result from poly A:U activation of a nylon wool adherent, T suppressor cell, capable of diminishing the response of normal spleen cells exposed to antigen on co-culture.",

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AB - Pretreatment of mouse spleen cells with polyadenylic-polyuridylic acid complexes (poly A:U) either in vivo or in vitro 24 hr prior to addition of antigen, resulted in a substantial time dependent decrease in anti-SRBC PFC. Enhancement was observed 6 hr after poly A:U, while inhibition did not become evident until 24 hr after pretreatment. Inhibition of the PFC response appeared to result from poly A:U activation of a nylon wool adherent, T suppressor cell, capable of diminishing the response of normal spleen cells exposed to antigen on co-culture.

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Regulation of the immune system by synthetic polynucleotides. VII. Suppression induced by pretreatment with poly A: U

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