Regulation of the immune system by synthetic polynucleotides. VII. Suppression induced by pretreatment with poly A: U

Clarice K. Morris, Arthur G. Johnson

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Pretreatment of mouse spleen cells with polyadenylic-polyuridylic acid complexes (poly A:U) either in vivo or in vitro 24 hr prior to addition of antigen, resulted in a substantial time dependent decrease in anti-SRBC PFC. Enhancement was observed 6 hr after poly A:U, while inhibition did not become evident until 24 hr after pretreatment. Inhibition of the PFC response appeared to result from poly A:U activation of a nylon wool adherent, T suppressor cell, capable of diminishing the response of normal spleen cells exposed to antigen on co-culture.

Original languageEnglish (US)
Pages (from-to)345-354
Number of pages10
JournalCellular Immunology
Volume39
Issue number2
DOIs
StatePublished - Sep 1 1978

Bibliographical note

Funding Information:
1 This work was supported by USPHS

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