Regulation of the immune system by synthetic polynucleotides. VI. Amplification of the immune response in young and aging mice

I. H. Han, A. G. Johnson

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Model systems for study of the action of adjuvants in immunodeficient states were developed in 10 to 14 day old BALB/aj mice and aging BALB/aj mice (12 to 16 mth). With sheep red blood cells as antigen polyadenylic polyuridylic polyuridylic acid complexes (poly A:U) were found to be stimulatory in both the neonatal and aging mice. The effect of poly A:U was similar to that seen when 5 x 106 106 thymocytes from immunologically mature mice were given with antigen. Cell free supernatant fluids induced by incubation of poly A:U with thymocytes likewise were capable of restoring the number of antibody forming cells to normalcy in aging mice.

Original languageEnglish (US)
Pages (from-to)423-427
Number of pages5
JournalJournal of Immunology
Volume117
Issue number2
StatePublished - Dec 1 1976

Fingerprint Dive into the research topics of 'Regulation of the immune system by synthetic polynucleotides. VI. Amplification of the immune response in young and aging mice'. Together they form a unique fingerprint.

Cite this