Model systems for study of the action of adjuvants in immunodeficient states were developed in 10 to 14 day old BALB/aj mice and aging BALB/aj mice (12 to 16 mth). With sheep red blood cells as antigen polyadenylic polyuridylic polyuridylic acid complexes (poly A:U) were found to be stimulatory in both the neonatal and aging mice. The effect of poly A:U was similar to that seen when 5 x 106 106 thymocytes from immunologically mature mice were given with antigen. Cell free supernatant fluids induced by incubation of poly A:U with thymocytes likewise were capable of restoring the number of antibody forming cells to normalcy in aging mice.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Immunology|
|State||Published - Dec 1 1976|