Regulation of Nlrp3 inflammasome by dietary metabolites

Christina Camell, Emily Goldberg, Vishwa Deep Dixit

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

The bidirectional communication between innate immune cells and energy metabolism is now widely appreciated to regulate homeostasis as well as chronic diseases that emerge from dysregulated inflammation. Macronutrients-derived from diet or endogenous pathways that generate and divert metabolites into energetic or biosynthetic pathways - regulate the initiation, duration and cessation of the inflammatory response. The NLRP3 inflammasome is an important innate sensor of structurally diverse metabolic damage-associated molecular patterns (DAMPs) that has been implicated in a wide range of inflammatory disorders associated with caloric excess, adiposity and aging. Understanding the regulators of immune-metabolic interactions and their contribution towards chronic disease mechanisms, therefore, has the potential to reduce disease pathology, improve quality of life in elderly and promote the extension of healthspan. Just as specialized subsets of immune cells dampen inflammation through the production of negative regulatory cytokines; specific immunoregulatory metabolites can deactivate inflammasome-mediated immune activation. Here, we highlight the role of energy substrates, alternative fuels and metabolic DAMPs in the regulation of the NLRP3 inflammasome and discuss potential dietary interventions that may impact sterile inflammatory disease.

Original languageEnglish (US)
Pages (from-to)334-342
Number of pages9
JournalSeminars in Immunology
Volume27
Issue number5
DOIs
StatePublished - Sep 1 2015

Fingerprint

Inflammasomes
Chronic Disease
Inflammation
Biosynthetic Pathways
Adiposity
Energy Metabolism
Homeostasis
Communication
Quality of Life
Pathology
Cytokines
Diet

Keywords

  • DAMP
  • Dietary intervention
  • Fatty acids
  • Ketones
  • Macrophage
  • Metabolite
  • Nlrp3 inflammasome
  • Sterile inflammation

Cite this

Regulation of Nlrp3 inflammasome by dietary metabolites. / Camell, Christina; Goldberg, Emily; Dixit, Vishwa Deep.

In: Seminars in Immunology, Vol. 27, No. 5, 01.09.2015, p. 334-342.

Research output: Contribution to journalReview article

Camell, Christina ; Goldberg, Emily ; Dixit, Vishwa Deep. / Regulation of Nlrp3 inflammasome by dietary metabolites. In: Seminars in Immunology. 2015 ; Vol. 27, No. 5. pp. 334-342.
@article{7a8277a3616249b1940c306e8dec782a,
title = "Regulation of Nlrp3 inflammasome by dietary metabolites",
abstract = "The bidirectional communication between innate immune cells and energy metabolism is now widely appreciated to regulate homeostasis as well as chronic diseases that emerge from dysregulated inflammation. Macronutrients-derived from diet or endogenous pathways that generate and divert metabolites into energetic or biosynthetic pathways - regulate the initiation, duration and cessation of the inflammatory response. The NLRP3 inflammasome is an important innate sensor of structurally diverse metabolic damage-associated molecular patterns (DAMPs) that has been implicated in a wide range of inflammatory disorders associated with caloric excess, adiposity and aging. Understanding the regulators of immune-metabolic interactions and their contribution towards chronic disease mechanisms, therefore, has the potential to reduce disease pathology, improve quality of life in elderly and promote the extension of healthspan. Just as specialized subsets of immune cells dampen inflammation through the production of negative regulatory cytokines; specific immunoregulatory metabolites can deactivate inflammasome-mediated immune activation. Here, we highlight the role of energy substrates, alternative fuels and metabolic DAMPs in the regulation of the NLRP3 inflammasome and discuss potential dietary interventions that may impact sterile inflammatory disease.",
keywords = "DAMP, Dietary intervention, Fatty acids, Ketones, Macrophage, Metabolite, Nlrp3 inflammasome, Sterile inflammation",
author = "Christina Camell and Emily Goldberg and Dixit, {Vishwa Deep}",
year = "2015",
month = "9",
day = "1",
doi = "10.1016/j.smim.2015.10.004",
language = "English (US)",
volume = "27",
pages = "334--342",
journal = "Seminars in Immunology",
issn = "1044-5323",
publisher = "Academic Press Inc.",
number = "5",

}

TY - JOUR

T1 - Regulation of Nlrp3 inflammasome by dietary metabolites

AU - Camell, Christina

AU - Goldberg, Emily

AU - Dixit, Vishwa Deep

PY - 2015/9/1

Y1 - 2015/9/1

N2 - The bidirectional communication between innate immune cells and energy metabolism is now widely appreciated to regulate homeostasis as well as chronic diseases that emerge from dysregulated inflammation. Macronutrients-derived from diet or endogenous pathways that generate and divert metabolites into energetic or biosynthetic pathways - regulate the initiation, duration and cessation of the inflammatory response. The NLRP3 inflammasome is an important innate sensor of structurally diverse metabolic damage-associated molecular patterns (DAMPs) that has been implicated in a wide range of inflammatory disorders associated with caloric excess, adiposity and aging. Understanding the regulators of immune-metabolic interactions and their contribution towards chronic disease mechanisms, therefore, has the potential to reduce disease pathology, improve quality of life in elderly and promote the extension of healthspan. Just as specialized subsets of immune cells dampen inflammation through the production of negative regulatory cytokines; specific immunoregulatory metabolites can deactivate inflammasome-mediated immune activation. Here, we highlight the role of energy substrates, alternative fuels and metabolic DAMPs in the regulation of the NLRP3 inflammasome and discuss potential dietary interventions that may impact sterile inflammatory disease.

AB - The bidirectional communication between innate immune cells and energy metabolism is now widely appreciated to regulate homeostasis as well as chronic diseases that emerge from dysregulated inflammation. Macronutrients-derived from diet or endogenous pathways that generate and divert metabolites into energetic or biosynthetic pathways - regulate the initiation, duration and cessation of the inflammatory response. The NLRP3 inflammasome is an important innate sensor of structurally diverse metabolic damage-associated molecular patterns (DAMPs) that has been implicated in a wide range of inflammatory disorders associated with caloric excess, adiposity and aging. Understanding the regulators of immune-metabolic interactions and their contribution towards chronic disease mechanisms, therefore, has the potential to reduce disease pathology, improve quality of life in elderly and promote the extension of healthspan. Just as specialized subsets of immune cells dampen inflammation through the production of negative regulatory cytokines; specific immunoregulatory metabolites can deactivate inflammasome-mediated immune activation. Here, we highlight the role of energy substrates, alternative fuels and metabolic DAMPs in the regulation of the NLRP3 inflammasome and discuss potential dietary interventions that may impact sterile inflammatory disease.

KW - DAMP

KW - Dietary intervention

KW - Fatty acids

KW - Ketones

KW - Macrophage

KW - Metabolite

KW - Nlrp3 inflammasome

KW - Sterile inflammation

UR - http://www.scopus.com/inward/record.url?scp=84952876142&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84952876142&partnerID=8YFLogxK

U2 - 10.1016/j.smim.2015.10.004

DO - 10.1016/j.smim.2015.10.004

M3 - Review article

C2 - 26776831

AN - SCOPUS:84952876142

VL - 27

SP - 334

EP - 342

JO - Seminars in Immunology

JF - Seminars in Immunology

SN - 1044-5323

IS - 5

ER -