Regulation of Myocardial Prostaglandin Dehydrogenase Activity. The Role of Cyclic 3′,5′-AMP and Calcium Ions

Constantinos J. Limas, Jay N. Cohn

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

A prostaglandin dehydrogenase (sp act, 15 units/mg protein) was isolated from the canine myocardium. The enzyme oxidized the 15-hydroxy group of most prostaglandins tested except for PGBs and PGA2 which were poor substrates. It required NAD and intact sulfhydryl groups. Its activity was enhanced by cyclic 3′,5′-AMP at low concentrations (10-10 to 10-7 M) and inhibited by CaCl2. The significance of these findings for the control of myocardial prostaglandin levels is discussed.

Original languageEnglish (US)
Pages (from-to)1230-1234
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Volume142
Issue number4
DOIs
StatePublished - Apr 1973

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