Regulation of mouse brain tryptophan hydroxylase activity

T. M. Cho, H. H. Loh

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Drugs which alter the levels of serotonin, 5 hydroxyindoleacetic acid (5 HIAA) and noradrenaline were shown to affect tryptophan hydroxylase activity in the CNS. Relatively high doses of 5 HIAA and noradrenaline added in vitro also inhibit tryptophan hydroxylase. The possibility that brain serotonin biosynthesis is regulated via and end product feedback control mechanism is discussed.

Original languageEnglish (US)
Pages (from-to)215-219
Number of pages5
JournalPharmacology
Volume10
Issue number4
DOIs
StatePublished - Jan 1 1973

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