Regulation of Luteinizing Hormone/Human Chorionic Gonadotropin Receptor Expression: A Perspective

K. M.J. Menon, Utpal M. Munshi, Christine L. Clouser, Anil K. Nair

Research output: Contribution to journalShort surveypeer-review

67 Scopus citations

Abstract

The LH/hCG receptor, a member of the G protein coupled receptor family mediates the cellular actions of LH in the ovary. A considerable amount of information regarding its structure, mechanism of activation, and regulation of expression has emerged in recent years. Here we provide a brief overview of the current information on the structural organization of the receptor and the mechanism of receptor mediated signaling as well as an in-depth discussion on recent developments pertaining to the regulation of receptor expression. Specifically, we describe studies from our laboratory showing that the posttranscriptional regulation of the receptor involves an LH/hCG receptor mRNA-binding protein. We also propose a model to explain the loss of steady-state LH/hCG receptor mRNA levels during receptor down-regulation.

Original languageEnglish (US)
Pages (from-to)861-866
Number of pages6
JournalBiology of reproduction
Volume70
Issue number4
DOIs
StatePublished - Apr 2004

Keywords

  • Human chorionic gonadotropin
  • Luteinizing hormone
  • Mechanisms of hormone action

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