Regulation of leukocyte adhesion and signaling in inflammation and disease

S. M. Wahl, G. M. Feldman, J. B. McCarthy

Research output: Contribution to journalReview articlepeer-review

68 Scopus citations

Abstract

Cell adhesion molecules provide the foundation for cell communication, trafficking, and immune surveillance central to host defense. These adhesion molecules which include selectins, integrins and members of the Ig superfamily, provide a recognition system between leukocytes, endothelial cells and matrix molecules. Leukocyte-endothelial interactions initiate recruitment at sites of injury, infection and inflammation. Cell-cell and cell-matrix interactions also influence leukocyte phenotype and function. Dysregulation of these adhesion and signal transduction pathways can contribute to continued recruitment and persistent leukocyte activation with unresolved inflammation. Based on the pivotal role adhesive interactions play, the adhesion molecules provide potential targets for intervention. Selected synthetic fibronectin peptides, which inhibit leukocyte integrin binding and signal transduction in vitro, block recruitment and activation to limit inflammation in vivo.

Original languageEnglish (US)
Pages (from-to)789-796
Number of pages8
JournalJournal of Leukocyte Biology
Volume59
Issue number6
DOIs
StatePublished - Jun 1996

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