Regulation of glucose production by the liver

Robert C. Nordlie, James D. Foster, Alex J. Lange

Research output: Contribution to journalReview articlepeer-review

453 Scopus citations


Glucose is an essential nutrient for the human body. It is the major energy source for many cells, which depend on the bloodstream for a steady supply. Blood glucose levels, therefore, are carefully maintained. The liver plays a central role in this process by balancing the uptake and storage of glucose via glycogenesis and the release of glucose via glycogenolysis and gluconeogenesis. The several substrate cycles in the major metabolic pathways of the liver play key roles in the regulation of glucose production. In this review, we focus on the short- and long-term regulation glucose-6-phosphatase and its substrate cycle counterpart, glucokinase. The substrate cycle enzyme glucose-6-phosphatase catalyzes the terminal step in both the gluconeogenic and glycogenolytic pathways and is opposed by the glycolytic enzyme glucokinase. In addition, we include the regulation of GLUT 2, which facilitates the final step in the transport of glucose out of the liver and into the bloodstream.

Original languageEnglish (US)
Pages (from-to)379-406
Number of pages28
JournalAnnual review of nutrition
StatePublished - Aug 20 1999


  • Gene expression
  • Glucokinase
  • Glucose-6-phosphatase
  • Glucose-6-phosphate
  • Glut 2


Dive into the research topics of 'Regulation of glucose production by the liver'. Together they form a unique fingerprint.

Cite this