Regulation of experimental autoimmune encephalomyelitis by chemokines and chemokine receptors

Adam Elhofy, Kevin J. Kennedy, Brian T. Fife, William J. Karpus

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

Experimental autoimmune encephalomyelitis (EAE) is a T cell mediated demyelinating disease of the central nervous system (CNS) that serves as a model for multiple sclerosis (MS). Insights into the pathogenesis of this model may help scientists understand the human disease and aid in rational drug discovery. In this review we summarize the role of chemokines and chemokine receptors in disease pathogenesis and suggest a pathway of events that leads to demyelination and subsequent clinical disease manifestation.

Original languageEnglish (US)
Pages (from-to)167-175
Number of pages9
JournalImmunologic Research
Volume25
Issue number2
DOIs
StatePublished - 2002

Keywords

  • Autoimmune
  • Chemokinds
  • Chemokine receptors
  • Encephalomyelitis

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