Regulation of endogenous type C viruses: Evidence for transcriptional control of AKR viral expression

Judith A. Thomson; Philip J. Laipis; Gary S. Stein; Janet L. Stein; Marilyn R. Lander; Sisir K. Chattopadhyay

doi:10.1016/0042-6822(80)90468-7

Regulation of endogenous type C viruses: Evidence for transcriptional control of AKR viral expression

Judith A. Thomson, Philip J. Laipis, Gary S. Stein, Janet L. Stein, Marilyn R. Lander, Sisir K. Chattopadhyay

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Abstract

Nuclear and cytoplasmic RNAs isolated from AKR virus producer and virus-negative cell lines, as well as in vitro transcripts of chromatin isolated from these cells, were analyzed by nucleic acid hybridization using a ³H-labeled DNA complementary to the genome of the endogenous AKR ecotropic murine leukemia virus. Our results suggest that regulation of expression of the endogenous virogene sequences resides in part at the transcriptional level.

Original language	English (US)
Pages (from-to)	529-533
Number of pages	5
Journal	Virology
Volume	101
Issue number	2
DOIs	https://doi.org/10.1016/0042-6822(80)90468-7
State	Published - Mar 1980

Bibliographical note

Funding Information:
These studies were supported in part by Grant CA-18874 from the National Institutes of Health. We thank Drs. Kenneth Berns, Barry Kramer, and Arup Sen for helpful discussions, and Dr. Wallace Rowe of the National Institute of Allergy and Infectious Diseasesa nd Dr. Arthur Levine of the National Cancer Institute for encouragemenat nd support.

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title = "Regulation of endogenous type C viruses: Evidence for transcriptional control of AKR viral expression",

abstract = "Nuclear and cytoplasmic RNAs isolated from AKR virus producer and virus-negative cell lines, as well as in vitro transcripts of chromatin isolated from these cells, were analyzed by nucleic acid hybridization using a 3H-labeled DNA complementary to the genome of the endogenous AKR ecotropic murine leukemia virus. Our results suggest that regulation of expression of the endogenous virogene sequences resides in part at the transcriptional level.",

author = "Thomson, {Judith A.} and Laipis, {Philip J.} and Stein, {Gary S.} and Stein, {Janet L.} and Lander, {Marilyn R.} and Chattopadhyay, {Sisir K.}",

note = "Funding Information: These studies were supported in part by Grant CA-18874 from the National Institutes of Health. We thank Drs. Kenneth Berns, Barry Kramer, and Arup Sen for helpful discussions, and Dr. Wallace Rowe of the National Institute of Allergy and Infectious Diseasesa nd Dr. Arthur Levine of the National Cancer Institute for encouragemenat nd support.",

year = "1980",

month = mar,

doi = "10.1016/0042-6822(80)90468-7",

language = "English (US)",

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T1 - Regulation of endogenous type C viruses

T2 - Evidence for transcriptional control of AKR viral expression

AU - Thomson, Judith A.

AU - Laipis, Philip J.

AU - Stein, Gary S.

AU - Stein, Janet L.

AU - Lander, Marilyn R.

AU - Chattopadhyay, Sisir K.

N1 - Funding Information: These studies were supported in part by Grant CA-18874 from the National Institutes of Health. We thank Drs. Kenneth Berns, Barry Kramer, and Arup Sen for helpful discussions, and Dr. Wallace Rowe of the National Institute of Allergy and Infectious Diseasesa nd Dr. Arthur Levine of the National Cancer Institute for encouragemenat nd support.

PY - 1980/3

Y1 - 1980/3

N2 - Nuclear and cytoplasmic RNAs isolated from AKR virus producer and virus-negative cell lines, as well as in vitro transcripts of chromatin isolated from these cells, were analyzed by nucleic acid hybridization using a 3H-labeled DNA complementary to the genome of the endogenous AKR ecotropic murine leukemia virus. Our results suggest that regulation of expression of the endogenous virogene sequences resides in part at the transcriptional level.

AB - Nuclear and cytoplasmic RNAs isolated from AKR virus producer and virus-negative cell lines, as well as in vitro transcripts of chromatin isolated from these cells, were analyzed by nucleic acid hybridization using a 3H-labeled DNA complementary to the genome of the endogenous AKR ecotropic murine leukemia virus. Our results suggest that regulation of expression of the endogenous virogene sequences resides in part at the transcriptional level.

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Regulation of endogenous type C viruses: Evidence for transcriptional control of AKR viral expression

Abstract

Bibliographical note

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